BACKGROUND: Donor hepatectomy for living donor liver transplantation accompanies physio-morphological changes of the liver and spleen. Therefore, the long-term consequences of these organs should be characterized to ensure donor's safety. METHODS: A total of 382 right liver harvests for liver transplantation were performed from October 2000 to February 2011. Clinical parameters across donor operations were compared, and the associations were investigated. RESULTS: The remaining liver grew continually, reaching 81.5 ± 11.2% of the entire liver until 6 months after donation. The spleen grew to 143.1 ± 28.8% of the pre-donation value within 1 week after surgery, and thereafter, its size decreased gradually to 130.6 ± 25.1% at 6 months. At 6 months post-donation, 48.1% (114/237) of donors showed an increase of ≥30% in splenic volume, and 15.9% (50/315) of donors exhibited a decrease of ≥30% in platelet count. However, patients with splenic enlargement and/or decrease in platelet count at 6 months post-donation were not different in liver function, liver regeneration, or overall complications. CONCLUSIONS: Although splenic enlargement and/or decrease in platelet count can persist for more than 6 months after donation in patient population after donor right hepatectomy, such a change did not impact donor's safety.
BACKGROUND:Donor hepatectomy for living donor liver transplantation accompanies physio-morphological changes of the liver and spleen. Therefore, the long-term consequences of these organs should be characterized to ensure donor's safety. METHODS: A total of 382 right liver harvests for liver transplantation were performed from October 2000 to February 2011. Clinical parameters across donor operations were compared, and the associations were investigated. RESULTS: The remaining liver grew continually, reaching 81.5 ± 11.2% of the entire liver until 6 months after donation. The spleen grew to 143.1 ± 28.8% of the pre-donation value within 1 week after surgery, and thereafter, its size decreased gradually to 130.6 ± 25.1% at 6 months. At 6 months post-donation, 48.1% (114/237) of donors showed an increase of ≥30% in splenic volume, and 15.9% (50/315) of donors exhibited a decrease of ≥30% in platelet count. However, patients with splenic enlargement and/or decrease in platelet count at 6 months post-donation were not different in liver function, liver regeneration, or overall complications. CONCLUSIONS: Although splenic enlargement and/or decrease in platelet count can persist for more than 6 months after donation in patient population after donor right hepatectomy, such a change did not impact donor's safety.
Authors: Rafik M Ghobrial; Chris E Freise; James F Trotter; Lan Tong; Akinlolu O Ojo; Jeffrey H Fair; Robert A Fisher; Jean C Emond; Alan J Koffron; Timothy L Pruett; Kim M Olthoff Journal: Gastroenterology Date: 2008-04-22 Impact factor: 22.682
Authors: Rafik M Ghobrial; Sammy Saab; Charles Lassman; David S k Lu; Steven Raman; Piyagorn Limanond; Greg Kunder; Karyn Marks; Farin Amersi; Dean Anselmo; Pauline Chen; Douglas Farmer; Steven Han; Francisco Durazo; Leonard I Goldstein; Ronald W Busuttil Journal: Liver Transpl Date: 2002-10 Impact factor: 5.799
Authors: Jean C Emond; Robert A Fisher; Gregory Everson; Benjamin Samstein; James J Pomposelli; Binsheng Zhao; Sarah Forney; Kim M Olthoff; Talia B Baker; Brenda W Gillespie; Robert M Merion Journal: Liver Transpl Date: 2015-02 Impact factor: 5.799