Literature DB >> 23838779

Decline in immature transitional B cells after hepatitis B vaccination in hepatitis B positive newborns.

Shikha Shrivastava1, Nirupama TrehanPati, Shyam Kottilil, Shiv Kumar Sarin.   

Abstract

Humoral immune responses are protective against hepatitis B virus (HBV) infection. We characterized B-cell phenotypic changes in infants of hepatitis B surface antigen positive mothers compared with normal and hepatitis B surface antigen negative infants at birth and 1 year after HBV immunization. Hepatitis B surface antigen positive infants had higher immature transitional B cells at birth, which normalized a year after immunization. Immature B-cell response to neonatal HBV exposure is associated with maternal-child transmission of HBV.

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Year:  2013        PMID： 23838779      PMCID： PMC3708314          DOI： 10.1097/INF.0b013e31828df344

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  10 in total

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Review 5.  Neonatal and early life vaccinology.

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Journal:  J Exp Med       Date:  2008-07-14       Impact factor: 14.307
  10 in total
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Review 2.  Hepatitis B and Pregnancy: Virologic and Immunologic Characteristics.

Authors:  Shivali S Joshi; Carla S Coffin
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Review 4.  Immunological mechanisms of hepatitis B virus persistence in newborns.

Authors:  Nirupma Trehanpati; Syed Hissar; Shikha Shrivastav; Shiv K Sarin
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  4 in total

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