AIM: The present study was planned to determine the effects of regular exercise program on hematopoietic stem cell (HSC) mobilization prior to autologous stem cell transplantation. METHOD: Twenty-two consecutive patients were enrolled in the study. A regular 20 min exercise program was administered to the patients. The hematopoietic stem cell mobilization outcome, number of Granulocyte Colony-Stimulating Factor (G-CSF) and aphaeresis application days were compared with 20 case-matched controls who did not receive exercise program during HSC mobilization. RESULTS: The median number of CD34(+) stem cells collected in the exercise and control groups were 8.15 × 10(6)/kg (range: 2.85-33.06 × 10(6)/kg) and 7.3 × 10(6)/kg (range: 1.78-25.9 × 10(6)/kg), respectively (p=0.696). G-CSF was administered for a median of 8 days (range, 5-10) in the exercise group and 8 days (range, 5-12) in the control group (p=0.848). The median apheresis duration was 1 day (range, 1-3) in both exercise and control groups (p=0.226). CONCLUSION: Exercise seems to have a positive impact on stem cell mobilization though without statistical significance.
AIM: The present study was planned to determine the effects of regular exercise program on hematopoietic stem cell (HSC) mobilization prior to autologous stem cell transplantation. METHOD: Twenty-two consecutive patients were enrolled in the study. A regular 20 min exercise program was administered to the patients. The hematopoietic stem cell mobilization outcome, number of Granulocyte Colony-Stimulating Factor (G-CSF) and aphaeresis application days were compared with 20 case-matched controls who did not receive exercise program during HSC mobilization. RESULTS: The median number of CD34(+) stem cells collected in the exercise and control groups were 8.15 × 10(6)/kg (range: 2.85-33.06 × 10(6)/kg) and 7.3 × 10(6)/kg (range: 1.78-25.9 × 10(6)/kg), respectively (p=0.696). G-CSF was administered for a median of 8 days (range, 5-10) in the exercise group and 8 days (range, 5-12) in the control group (p=0.848). The median apheresis duration was 1 day (range, 1-3) in both exercise and control groups (p=0.226). CONCLUSION: Exercise seems to have a positive impact on stem cell mobilization though without statistical significance.
Authors: Rian Q Landers-Ramos; Kelsey J Corrigan; Lisa M Guth; Christine N Altom; Espen E Spangenburg; Steven J Prior; James M Hagberg Journal: Appl Physiol Nutr Metab Date: 2016-03-28 Impact factor: 2.665
Authors: Maria F Arisi; Erica N Chirico; Roxanne Sebeny; Geetha Muthukumaran; Anbin Mu; Bart C De Jonghe; Kenneth B Margulies; Joseph R Libonati Journal: Physiol Rep Date: 2017-06
Authors: W A Wood; B Phillips; A E Smith-Ryan; D Wilson; A M Deal; C Bailey; M Meeneghan; B B Reeve; E M Basch; A V Bennett; T C Shea; C L Battaglini Journal: Bone Marrow Transplant Date: 2016-03-21 Impact factor: 5.483