Dorothea Peters1, Boel Bengtsson, Anders Heijl. 1. Department of Clinical Sciences in Malmö, Ophthalmology, Lund University, Skåne University Hospital, Malmö, Sweden.
Abstract
PURPOSE: To investigate factors associated with bilateral glaucoma blindness, particularly factors available at the time of diagnosis. METHODS: Retrospective chart review of all patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEXG) followed at the Department of Ophthalmology or Low Vision Center of Skåne University Hospital, Malmö, Sweden, who died between January 2006 and June 2010. Disease stage at diagnosis was defined by a simplified version of Mills' glaucoma staging system using perimetric mean deviation (MD) to define six stages of severity. Blindness was defined according to WHO criteria. We used logistic regression analysis to examine the association between risk factors and glaucoma blindness. RESULTS: Four hundred and 23 patients were included; 60% POAG and 40% PEXG. Sixty-four patients (15%) became blind from glaucoma. Blind patients had significantly longer mean duration with diagnosed disease than patients who did not go blind (14.8 years ± 5.8 versus 10.6 years ± 6.5, p < 0.001). The risk of blindness increased with higher intraocular pressure (IOP) (OR 1.08, 95% CI 1.03-1.13) and with each stage of more advanced field loss at time of diagnosis (OR 1.80 95% CI 1.34-2.41). Older age at death was also associated with an increased risk of blindness (OR 1.09 95% CI 1.03-1.14), while age at diagnosis was unimportant. PEXG was not an independent risk factor for blindness. CONCLUSIONS: Higher IOP and worse visual field status at baseline were important risk factors, as was older age at death.
PURPOSE: To investigate factors associated with bilateral glaucoma blindness, particularly factors available at the time of diagnosis. METHODS: Retrospective chart review of all patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEXG) followed at the Department of Ophthalmology or Low Vision Center of Skåne University Hospital, Malmö, Sweden, who died between January 2006 and June 2010. Disease stage at diagnosis was defined by a simplified version of Mills' glaucoma staging system using perimetric mean deviation (MD) to define six stages of severity. Blindness was defined according to WHO criteria. We used logistic regression analysis to examine the association between risk factors and glaucoma blindness. RESULTS: Four hundred and 23 patients were included; 60% POAG and 40% PEXG. Sixty-four patients (15%) became blind from glaucoma. Blind patients had significantly longer mean duration with diagnosed disease than patients who did not go blind (14.8 years ± 5.8 versus 10.6 years ± 6.5, p < 0.001). The risk of blindness increased with higher intraocular pressure (IOP) (OR 1.08, 95% CI 1.03-1.13) and with each stage of more advanced field loss at time of diagnosis (OR 1.80 95% CI 1.34-2.41). Older age at death was also associated with an increased risk of blindness (OR 1.09 95% CI 1.03-1.14), while age at diagnosis was unimportant. PEXG was not an independent risk factor for blindness. CONCLUSIONS: Higher IOP and worse visual field status at baseline were important risk factors, as was older age at death.
Authors: Henriët Springelkamp; Adriana I Iglesias; Aniket Mishra; René Höhn; Robert Wojciechowski; Anthony P Khawaja; Abhishek Nag; Ya Xing Wang; Jie Jin Wang; Gabriel Cuellar-Partida; Jane Gibson; Jessica N Cooke Bailey; Eranga N Vithana; Puya Gharahkhani; Thibaud Boutin; Wishal D Ramdas; Tanja Zeller; Robert N Luben; Ekaterina Yonova-Doing; Ananth C Viswanathan; Seyhan Yazar; Angela J Cree; Jonathan L Haines; Jia Yu Koh; Emmanuelle Souzeau; James F Wilson; Najaf Amin; Christian Müller; Cristina Venturini; Lisa S Kearns; Jae Hee Kang; Yih Chung Tham; Tiger Zhou; Elisabeth M van Leeuwen; Stefan Nickels; Paul Sanfilippo; Jiemin Liao; Herma van der Linde; Wanting Zhao; Leonieke M E van Koolwijk; Li Zheng; Fernando Rivadeneira; Mani Baskaran; Sven J van der Lee; Shamira Perera; Paulus T V M de Jong; Ben A Oostra; André G Uitterlinden; Qiao Fan; Albert Hofman; E-Shyong Tai; Johannes R Vingerling; Xueling Sim; Roger C W Wolfs; Yik Ying Teo; Hans G Lemij; Chiea Chuen Khor; Rob Willemsen; Karl J Lackner; Tin Aung; Nomdo M Jansonius; Grant Montgomery; Philipp S Wild; Terri L Young; Kathryn P Burdon; Pirro G Hysi; Louis R Pasquale; Tien Yin Wong; Caroline C W Klaver; Alex W Hewitt; Jost B Jonas; Paul Mitchell; Andrew J Lotery; Paul J Foster; Veronique Vitart; Norbert Pfeiffer; Jamie E Craig; David A Mackey; Christopher J Hammond; Janey L Wiggs; Ching-Yu Cheng; Cornelia M van Duijn; Stuart MacGregor Journal: Hum Mol Genet Date: 2017-01-15 Impact factor: 6.150
Authors: James R Tribble; Flora Hui; Melissa Jöe; Katharina Bell; Vicki Chrysostomou; Jonathan G Crowston; Pete A Williams Journal: Cells Date: 2021-02-01 Impact factor: 6.600