BACKGROUND: Little is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC. METHODS: We chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched-pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival. RESULTS: Of the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease-free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant. CONCLUSION: Targeted inhibition of tumor EGFR expression may be a new approach to treating SNSCC.
BACKGROUND: Little is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC. METHODS: We chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched-pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival. RESULTS: Of the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease-free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant. CONCLUSION: Targeted inhibition of tumorEGFR expression may be a new approach to treating SNSCC.
Authors: Francesco Perri; Raffaele Addeo; Manuel Conson; Adriana Faiella; Giuseppina Della Vittoria Scarpati; Gabriella Torre; Angela Di Biase; Paola Romanelli; Carlo Buonerba; Giuseppe Di Lorenzo; Antonio Daponte; Francesco Caponigro; Salvatore Pisconti; Roberto Pacelli; Vincenzo Ravo; Paolo Muto; Raffaele Solla Journal: Oncol Lett Date: 2017-01-11 Impact factor: 2.967
Authors: Cristina García-Inclán; Alejandro López-Hernández; Marta Alonso-Guervós; Eva Allonca; Sira Potes; Santiago Melón; Fernando López; José Luis Llorente; Mario Hermsen Journal: Sci Rep Date: 2014-05-12 Impact factor: 4.379
Authors: Anish Sharma; Alice L Tang; Vinita Takiar; Trisha M Wise-Draper; Scott M Langevin Journal: Cancers (Basel) Date: 2021-07-22 Impact factor: 6.639