Kathy Dujardin1, Pascal Sockeel, Anne-Sophie Carette, Marie Delliaux, Luc Defebvre. 1. Laboratoire de Neurosciences Fonctionnelles et Pathologies, EA 4559, Université Lille, Lille, France; Neurologie et Pathologie du Mouvement, Neurologie A, Hôpital Salengro, Centre Hospitalier Universitaire, Lille, France.
Abstract
BACKGROUND: Apathy is an invalidating behavioral disorder that must always be screened for and assessed in patients with Parkinson's disease (PD). The Lille Apathy Rating Scale (LARS) has been validated in several different contexts, but the lengthy administration time means that it is mostly recommended for research use. The aim of the present study was to validate a short form of the LARS for use in everyday practice. METHODS: In total, 416 patients with PD and 56 healthy controls participated in the study. Apathy, depression, motor symptoms, and overall cognitive efficiency were assessed. The most discriminant items of the LARS for apathy detection were selected using multiple indicators. RESULTS: A subset of 12 items (constituting the short-form LARS) showed the best convergence. Concurrent and criterion-related validity, internal consistency, test-retest reliability, and inter-rater reliability were very good. CONCLUSIONS: The short-form LARS is a reliable, practical, patient interview-based instrument for assessing apathy in everyday clinical practice.
BACKGROUND: Apathy is an invalidating behavioral disorder that must always be screened for and assessed in patients with Parkinson's disease (PD). The Lille Apathy Rating Scale (LARS) has been validated in several different contexts, but the lengthy administration time means that it is mostly recommended for research use. The aim of the present study was to validate a short form of the LARS for use in everyday practice. METHODS: In total, 416 patients with PD and 56 healthy controls participated in the study. Apathy, depression, motor symptoms, and overall cognitive efficiency were assessed. The most discriminant items of the LARS for apathy detection were selected using multiple indicators. RESULTS: A subset of 12 items (constituting the short-form LARS) showed the best convergence. Concurrent and criterion-related validity, internal consistency, test-retest reliability, and inter-rater reliability were very good. CONCLUSIONS: The short-form LARS is a reliable, practical, patient interview-based instrument for assessing apathy in everyday clinical practice.
Authors: V Cochen De Cock; D G Dotov; P Ihalainen; V Bégel; F Galtier; C Lebrun; M C Picot; V Driss; N Landragin; C Geny; B Bardy; S Dalla Bella Journal: NPJ Parkinsons Dis Date: 2018-03-23