Literature DB >> 23836181

Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat model of pneumonia.

Sami Hraiech1, Antoine Roch, Hubert Lepidi, Thérèse Atieh, Gilles Audoly, Jean-Marc Rolain, Didier Raoult, Jean-Michel Brunel, Laurent Papazian, Fabienne Brégeon.   

Abstract

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).

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Year:  2013        PMID： 23836181      PMCID： PMC3811450          DOI： 10.1128/AAC.00700-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Acinetobacter baumannii resistant to colistin alters its antibiotic resistance profile: a case report from Spain.

Authors:  Rafael López-Rojas; Manuel Enrique Jiménez-Mejías; José Antonio Lepe; Jerónimo Pachón
Journal:  J Infect Dis       Date:  2011-10-01       Impact factor: 5.226

2.  Acinetobacter baumannii resistant to colistin with impaired virulence: a case report from France.

Authors:  Jean-Marc Rolain; Antoine Roch; Matthias Castanier; Laurent Papazian; Didier Raoult
Journal:  J Infect Dis       Date:  2011-10-01       Impact factor: 5.226

3.  Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France.

Authors:  Jean-Marc Rolain; Seydina M Diene; Marie Kempf; Gregory Gimenez; Catherine Robert; Didier Raoult
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

Review 4.  Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Authors:  Alejandro Beceiro; María Tomás; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

5.  Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia.

Authors:  Sami Hraiech; Fabienne Brégeon; Jean-Michel Brunel; Jean-Marc Rolain; Hubert Lepidi; Véronique Andrieu; Didier Raoult; Laurent Papazian; Antoine Roch
Journal:  J Antimicrob Chemother       Date:  2012-06-28       Impact factor: 5.790

6.  Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

Authors:  Rafael López-Rojas; Juan Domínguez-Herrera; Michael J McConnell; Fernando Docobo-Peréz; Younes Smani; María Fernández-Reyes; Luis Rivas; Jerónimo Pachón
Journal:  J Infect Dis       Date:  2011-01-07       Impact factor: 5.226

7.  Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation.

Authors:  Marie Kempf; Jean-Marc Rolain; Saïd Azza; Seydina Diene; Marie-Laure Joly-Guillou; Gregory Dubourg; Philippe Colson; Laurent Papazian; Hervé Richet; Pierre-Edouard Fournier; Amandina Ribeiro; Didier Raoult
Journal:  APMIS       Date:  2012-06-28       Impact factor: 3.205

8.  Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains.

Authors:  Jian Li; Roger L Nation; Roxanne J Owen; Stephanie Wong; Denis Spelman; Clare Franklin
Journal:  Clin Infect Dis       Date:  2007-07-17       Impact factor: 9.079

9.  The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective.

Authors:  María Fernández-Reyes; Manuel Rodríguez-Falcón; Cristina Chiva; Jerónimo Pachón; David Andreu; Luis Rivas
Journal:  Proteomics       Date:  2009-03       Impact factor: 3.984

10.  Comparative genomics of multidrug resistance in Acinetobacter baumannii.

Authors:  Pierre-Edouard Fournier; David Vallenet; Valérie Barbe; Stéphane Audic; Hiroyuki Ogata; Laurent Poirel; Hervé Richet; Catherine Robert; Sophie Mangenot; Chantal Abergel; Patrice Nordmann; Jean Weissenbach; Didier Raoult; Jean-Michel Claverie
Journal:  PLoS Genet       Date:  2006-01-13       Impact factor: 5.917
  10 in total
  19 in total

Review 1.  Extremely and pandrug-resistant bacteria extra-deaths: myth or reality?

Authors:  Cédric Abat; Pierre-Edouard Fournier; Marie-Thérèse Jimeno; Jean-Marc Rolain; Didier Raoult
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2018-06-28       Impact factor: 3.267

Review 2.  Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.

Authors:  Darren Wong; Travis B Nielsen; Robert A Bonomo; Paul Pantapalangkoor; Brian Luna; Brad Spellberg
Journal:  Clin Microbiol Rev       Date:  2017-01       Impact factor: 26.132

Review 3.  Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria.

Authors:  Edward Geisinger; Ralph R Isberg
Journal:  J Infect Dis       Date:  2017-02-15       Impact factor: 5.226

4.  Transcriptional and Mutational Profiling of an Aminoglycoside-Resistant Pseudomonas aeruginosa Small-Colony Variant.

Authors:  Monika Schniederjans; Michal Koska; Susanne Häussler
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

Review 5.  Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria.

Authors:  Abiola O Olaitan; Serge Morand; Jean-Marc Rolain
Journal:  Front Microbiol       Date:  2014-11-26       Impact factor: 5.640

6.  Editorial commentary: Polymyxin-resistant Acinetobacter baumannii: urgent action needed.

Authors:  Jason M Pogue; David A Cohen; Dror Marchaim
Journal:  Clin Infect Dis       Date:  2015-01-28       Impact factor: 9.079

7.  Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia.

Authors:  Sami Hraiech; Julien Hiblot; John Lafleur; Hubert Lepidi; Laurent Papazian; Jean-Marc Rolain; Didier Raoult; Mikael Elias; Mark W Silby; Janek Bzdrenga; Fabienne Bregeon; Eric Chabriere
Journal:  PLoS One       Date:  2014-10-28       Impact factor: 3.240

Review 8.  Genetic Regulation of Virulence and Antibiotic Resistance in Acinetobacter baumannii.

Authors:  Carsten Kröger; Stefani C Kary; Kristina Schauer; Andrew D S Cameron
Journal:  Genes (Basel)       Date:  2016-12-28       Impact factor: 4.096

9.  Antimicrobial Resistance Mechanisms and Virulence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii Isolated from a Teaching Hospital in Taiwan.

Authors:  Noor Andryan Ilsan; Yuarn-Jang Lee; Shu-Chen Kuo; I-Hui Lee; Tzu-Wen Huang
Journal:  Microorganisms       Date:  2021-06-14

Review 10.  Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status.

Authors:  Sami Hraiech; Fabienne Brégeon; Jean-Marc Rolain
Journal:  Drug Des Devel Ther       Date:  2015-07-16       Impact factor: 4.162
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