OBJECTIVES/HYPOTHESIS: Previous studies have indicated that hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of myocardial infarction (MI). STUDY DESIGN: A retrospective cohort study. METHODS: Using the Taiwan Longitudinal Health Insurance Database, we compared patients diagnosed with SSHL between January 1, 2001, and December 31, 2006, (N = 44,830) with age-matched controls (1:1) (N = 44,830). We followed up on each patient until the end of 2009 to evaluate the incidence of MI for a minimum period of 3 years after their initial SSHL diagnosis. RESULTS: We found that after adjusting for potential confounds with an adjusted hazard ratio (HR) of 1.254 (95% confidence interval, 1.092-1.440, P < 0.05), patients with SSHL were more likely to suffer MI than the control population. When stratified by patient age, the incidence of MI was 1.62-fold and 1.28-fold higher for SSHL-diagnosed patients aged between 50 and 64 years and those aged ≥ 65 years (P = 0.0064 and P = 0.0001), respectively, than in the non-SSHL group. CONCLUSIONS: SSHL may confer an independent risk of MI. This observation may prompt the early detection and timely treatment of patients at a high risk of MI.
OBJECTIVES/HYPOTHESIS: Previous studies have indicated that hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the development of sudden sensorineural hearing loss (SSHL). The purpose of this study was to test the hypothesis that SSHL is a risk factor for the development of myocardial infarction (MI). STUDY DESIGN: A retrospective cohort study. METHODS: Using the Taiwan Longitudinal Health Insurance Database, we compared patients diagnosed with SSHL between January 1, 2001, and December 31, 2006, (N = 44,830) with age-matched controls (1:1) (N = 44,830). We followed up on each patient until the end of 2009 to evaluate the incidence of MI for a minimum period of 3 years after their initial SSHL diagnosis. RESULTS: We found that after adjusting for potential confounds with an adjusted hazard ratio (HR) of 1.254 (95% confidence interval, 1.092-1.440, P < 0.05), patients with SSHL were more likely to suffer MI than the control population. When stratified by patient age, the incidence of MI was 1.62-fold and 1.28-fold higher for SSHL-diagnosed patients aged between 50 and 64 years and those aged ≥ 65 years (P = 0.0064 and P = 0.0001), respectively, than in the non-SSHL group. CONCLUSIONS: SSHL may confer an independent risk of MI. This observation may prompt the early detection and timely treatment of patients at a high risk of MI.
Authors: Matthew G Crowson; Hillary Mulder; Derek D Cyr; Alan W Langman; Walter T Lee; Kourosh Parham; Melissa A Pynnonen; Kristine Schulz; Jennifer J Shin; David Witsell; Andrea Vambutas Journal: Otol Neurotol Date: 2018-08 Impact factor: 2.311
Authors: Su Young Jung; Haeng Seon Shim; Young Min Hah; Sang Hoon Kim; Seung Geun Yeo Journal: JAMA Otolaryngol Head Neck Surg Date: 2018-04-01 Impact factor: 6.223
Authors: Ann E M Liljas; S Goya Wannamethee; Peter H Whincup; Olia Papacosta; Kate Walters; Steve Iliffe; Lucy T Lennon; Livia A Carvalho; Sheena E Ramsay Journal: J Am Geriatr Soc Date: 2016-02 Impact factor: 5.562