Literature DB >> 23835779

Association of genetic variation with gene expression and protein abundance within the natriuretic peptide pathway.

David E Lanfear1, Bipin Sunkara, Jia Li, Sharad Rastogi, Ramesh C Gupta, Badri Padhukasahasram, L Keoki Williams, Hani N Sabbah.   

Abstract

The natriuretic peptide (NP) system is a critical physiologic pathway in heart failure with wide individual variability in functioning. We investigated the genetic component by testing the association of single nucleotide polymorphisms (SNP) with RNA and protein expression. Samples of DNA, RNA, and tissue from human kidney (n = 103) underwent genotyping, RT-PCR, and protein quantitation (in lysates), for four candidate genes [NP receptor 1 (NPR1), NPR2, and NPR3 and membrane metalloendopeptidase]. The association of genetic variation with expression was tested using linear regression for individual SNPs, and a principal components (PC) method for overall gene variation. Eleven SNPs in NPR2 were significantly associated with protein expression (false discovery rate ≤0.05), but not RNA quantity. RNA and protein quantity correlated poorly with each other. The PC analysis showed only NPR2 as significant. Assessment of the clinical impact of NPR2 genetic variation is needed.

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Year:  2013        PMID： 23835779      PMCID： PMC3795918          DOI： 10.1007/s12265-013-9491-y

Source DB:  PubMed          Journal:  J Cardiovasc Transl Res        ISSN： 1937-5387            Impact factor:   4.132


  24 in total

1.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

2.  Effect of nesiritide in patients with acute decompensated heart failure.

Authors:  C M O'Connor; R C Starling; A F Hernandez; P W Armstrong; K Dickstein; V Hasselblad; G M Heizer; M Komajda; B M Massie; J J V McMurray; M S Nieminen; C J Reist; J L Rouleau; K Swedberg; K F Adams; S D Anker; D Atar; A Battler; R Botero; N R Bohidar; J Butler; N Clausell; R Corbalán; M R Costanzo; U Dahlstrom; L I Deckelbaum; R Diaz; M E Dunlap; J A Ezekowitz; D Feldman; G M Felker; G C Fonarow; D Gennevois; S S Gottlieb; J A Hill; J E Hollander; J G Howlett; M P Hudson; R D Kociol; H Krum; A Laucevicius; W C Levy; G F Méndez; M Metra; S Mittal; B-H Oh; N L Pereira; P Ponikowski; W H W Tang; W H Wilson; S Tanomsup; J R Teerlink; F Triposkiadis; R W Troughton; A A Voors; D J Whellan; F Zannad; R M Califf
Journal:  N Engl J Med       Date:  2011-07-07       Impact factor: 91.245

Review 3.  CD-NP: an innovative designer natriuretic peptide activator of particulate guanylyl cyclase receptors for cardiorenal disease.

Authors:  Paul M McKie; S Jeson Sangaralingham; John C Burnett
Journal:  Curr Heart Fail Rep       Date:  2010-09

4.  Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials.

Authors:  Jonathan D Sackner-Bernstein; Marcin Kowalski; Marshal Fox; Keith Aaronson
Journal:  JAMA       Date:  2005-04-20       Impact factor: 56.272

5.  Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group.

Authors:  W S Colucci; U Elkayam; D P Horton; W T Abraham; R C Bourge; A D Johnson; L E Wagoner; M M Givertz; C S Liang; M Neibaur; W H Haught; T H LeJemtel
Journal:  N Engl J Med       Date:  2000-07-27       Impact factor: 91.245

6.  Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis.

Authors:  Leigh J Ellmers; Nicola J A Scott; Jarkko Piuhola; Nobuyo Maeda; Oliver Smithies; Chris M Frampton; A Mark Richards; Vicky A Cameron
Journal:  J Mol Endocrinol       Date:  2007-02       Impact factor: 5.098

Review 7.  Genetic variation in the natriuretic peptide system and heart failure.

Authors:  David E Lanfear
Journal:  Heart Fail Rev       Date:  2008-10-11       Impact factor: 4.214

8.  The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16.

Authors:  Ping An; Odity Mukherjee; Pritam Chanda; Li Yao; Corinne D Engelman; Chien-Hsun Huang; Tian Zheng; Ilija P Kovac; Marie-Pierre Dubé; Xueying Liang; Jia Li; Mariza de Andrade; Robert Culverhouse; Doerthe Malzahn; Alisa K Manning; Geraldine M Clarke; Jeesun Jung; Michael A Province
Journal:  Genet Epidemiol       Date:  2009       Impact factor: 2.135

9.  Genetic variation in the B-type natiuretic peptide pathway affects BNP levels.

Authors:  David E Lanfear; Joshua M Stolker; Sharon Marsh; Michael W Rich; Howard L McLeod
Journal:  Cardiovasc Drugs Ther       Date:  2007-03-03       Impact factor: 3.727

10.  Association tests based on the principal-component analysis.

Authors:  Sohee Oh; Taesung Park
Journal:  BMC Proc       Date:  2007-12-18
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  4 in total

1.  Genetic and nongenetic factors influencing pharmacokinetics of B-type natriuretic peptide.

Authors:  David E Lanfear; Sheryl Chow; Badri Padhukasahasram; Jia Li; David Langholz; W H Wilson Tang; L Keoki Williams; Hani N Sabbah
Journal:  J Card Fail       Date:  2014-06-28       Impact factor: 5.712

Review 2.  Practical Pharmacogenomic Approaches to Heart Failure Therapeutics.

Authors:  Chayakrit Krittanawong; Amalia Namath; David E Lanfear; W H Wilson Tang
Journal:  Curr Treat Options Cardiovasc Med       Date:  2016-10

Review 3.  Pharmacogenomics of the Natriuretic Peptide System in Heart Failure.

Authors:  Ahmed Abuzaanona; David Lanfear
Journal:  Curr Heart Fail Rep       Date:  2017-12

4.  Genetic Factors Influencing B-type Natriuretic Peptide-Mediated Production of Cyclic Guanosine Monophosphate and Blood Pressure Effects in Heart Failure Patients.

Authors:  David E Lanfear; Jia Li; Raza Abbas; Ricoung She; Badri Padhukasahasram; Ramesh C Gupta; David Langholz; W H Wilson Tang; L Keoki Williams; Hani N Sabbah; Sheryl L Chow
Journal:  J Cardiovasc Transl Res       Date:  2015-11-20       Impact factor: 4.132
  4 in total

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