J H Baek1, G Kinrys, A A Nierenberg. 1. Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA, USA.
Abstract
OBJECTIVE: Tremor occurs frequently as a side-effect of lithium, and it is, however, easily overlooked in the clinical setting. In this article, we attempt to review the pathophysiology and the clinical approach of lithium tremor. METHOD: We searched the Pubmed and Cochrane Library for relevant articles up to the year 2012. Sixty-four articles including 10 review papers, 3 clinical trials, and 12 case reports were reviewed. RESULTS: Lithium tremor is classified as a postural tremor and subcategorized as an exaggerated physiologic tremor. Differential diagnosis includes metabolic abnormalities, benign essential tremor, Parkinson's disease, and lithium toxicity. Various methods of evaluating lithium tremor and treatment options are discussed. CONCLUSION: When lithium tremor has developed, thorough history taking, physical examination, and blood examination including serum lithium level are needed. Pharmacotherapy is indicated only in patients with disabling tremor.
OBJECTIVE:Tremor occurs frequently as a side-effect of lithium, and it is, however, easily overlooked in the clinical setting. In this article, we attempt to review the pathophysiology and the clinical approach of lithiumtremor. METHOD: We searched the Pubmed and Cochrane Library for relevant articles up to the year 2012. Sixty-four articles including 10 review papers, 3 clinical trials, and 12 case reports were reviewed. RESULTS:Lithiumtremor is classified as a postural tremor and subcategorized as an exaggerated physiologic tremor. Differential diagnosis includes metabolic abnormalities, benign essential tremor, Parkinson's disease, and lithiumtoxicity. Various methods of evaluating lithiumtremor and treatment options are discussed. CONCLUSION: When lithiumtremor has developed, thorough history taking, physical examination, and blood examination including serum lithium level are needed. Pharmacotherapy is indicated only in patients with disabling tremor.
Authors: Jacob Taylor; William S Anderson; Jason Brandt; Zoltan Mari; Gregory M Pontone Journal: Am J Geriatr Psychiatry Date: 2016-09-03 Impact factor: 4.105
Authors: Ptolemaios Georgios Sarrigiannis; Panagiotis Zis; Zoe Charlotte Unwin; Daniel J Blackburn; Nigel Hoggard; Yifan Zhao; Stephen A Billings; Aijaz A Khan; John Yianni; Marios Hadjivassiliou Journal: Cerebellum Ataxias Date: 2019-05-22
Authors: Robert A Hauser; Jonathan M Meyer; Stewart A Factor; Cynthia L Comella; Caroline M Tanner; Rose Mary Xavier; Stanley N Caroff; Leslie Lundt Journal: CNS Spectr Date: 2020-11-20 Impact factor: 4.604