BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS:Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
Authors: C Straus; K Vasilakos; R J A Wilson; T Oshima; M Zelter; J-Ph Derenne; T Similowski; W A Whitelaw Journal: Bioessays Date: 2003-02 Impact factor: 4.345
Authors: M J Cossentino; K Mann; S P Armbruster; J M Lake; C Maydonovitch; R K H Wong Journal: Aliment Pharmacol Ther Date: 2012-03-20 Impact factor: 8.171
Authors: Christopher J Ehret; Yahya Almodallal; Jennifer G Le-Rademacher; Nichole A Martin; Michael R Moynagh; Arush Rajotia; Aminah Jatoi Journal: BMC Cancer Date: 2022-06-15 Impact factor: 4.638
Authors: Jia W Romito; Emily R Turner; John A Rosener; Landon Coldiron; Ashutosh Udipi; Linsey Nohrn; Jacob Tausiani; Bryan T Romito Journal: SAGE Open Med Date: 2021-06-03