PURPOSE: To evaluate in vitro the ability for an experimental anhydrous 0.454% w/w stannous fluoride dentifrice to occlude dentin tubules. METHODS: Scanning electron microscopy (SEM) was used to assess tubule occlusion and the resistance of the occlusion to dietary acid in a 4-day model, where bovine dentin was treated with product twice daily with acid challenges administered on Days 3 and 4. The reduction in hydraulic conductance of the dentin following treatment was also measured. RESULTS: The experimental stannous fluoride dentifrice was effective at reducing the hydraulic conductance of dentin by occluding tubules. The occlusion was resistant to challenge with grapefruit juice.
PURPOSE: To evaluate in vitro the ability for an experimental anhydrous 0.454% w/w stannous fluoride dentifrice to occlude dentin tubules. METHODS: Scanning electron microscopy (SEM) was used to assess tubule occlusion and the resistance of the occlusion to dietary acid in a 4-day model, where bovine dentin was treated with product twice daily with acid challenges administered on Days 3 and 4. The reduction in hydraulic conductance of the dentin following treatment was also measured. RESULTS: The experimental stannous fluoride dentifrice was effective at reducing the hydraulic conductance of dentin by occluding tubules. The occlusion was resistant to challenge with grapefruit juice.