OBJECTIVE: To assess the properties of adrenal lesions with and without known primary cancer and investigate predictors for differential diagnosis between benign and malignant adrenal enlargement. METHODS: This retrospective study used fluorine-18 fludeoxyglucose positron emission tomography (PET)/CT in 325 patients with adrenal lesions (229 with known primary cancer and 96 without primary cancer). Age, sex, the presence of right and left masses, nodules or hyperplasia, unenhanced attenuation, maximum standardised uptake value (SUVmax) ratio, and the presence of metastasis in other body parts and locations of the primary cancer were assessed. Univariate and multivariate analyses were used to assess variables associated with risk of adrenal metastasis. RESULTS: Patients with adrenal metastasis vs those without had a higher frequency of primary lung cancer (52.3% vs 30.7%) but a lower frequency of gastrointestinal cancer (7.9% vs 16.6%). The frequency of other abnormalities, including adenoma and hyperplasia, was similar between patients with and without known primary cancer. A higher proportion of patients with adrenal metastasis regardless of primary cancer site were younger, had a nodule or a mass, had an unenhanced attenuation of >10 HU, had an SUVmax ratio of >2.5, and had metastasis in other body parts. Analysis found independent associations of age, unenhanced attenuation of >10 HU, SUVmax ratio of >2.5 and the presence of metastasis in other body parts with adrenal metastasis. The combination of the four variables was strongly associated with adrenal metastasis. CONCLUSION: PET/CT was useful in characterising adrenal lesions as benign or malignant and helpful in identifying adrenal metastasis and cancer severity. ADVANCES IN KNOWLEDGE: PET/CT can help in the differential diagnosis between benign and malignant adrenal enlargement.
OBJECTIVE: To assess the properties of adrenal lesions with and without known primary cancer and investigate predictors for differential diagnosis between benign and malignant adrenal enlargement. METHODS: This retrospective study used fluorine-18 fludeoxyglucose positron emission tomography (PET)/CT in 325 patients with adrenal lesions (229 with known primary cancer and 96 without primary cancer). Age, sex, the presence of right and left masses, nodules or hyperplasia, unenhanced attenuation, maximum standardised uptake value (SUVmax) ratio, and the presence of metastasis in other body parts and locations of the primary cancer were assessed. Univariate and multivariate analyses were used to assess variables associated with risk of adrenal metastasis. RESULTS:Patients with adrenal metastasis vs those without had a higher frequency of primary lung cancer (52.3% vs 30.7%) but a lower frequency of gastrointestinal cancer (7.9% vs 16.6%). The frequency of other abnormalities, including adenoma and hyperplasia, was similar between patients with and without known primary cancer. A higher proportion of patients with adrenal metastasis regardless of primary cancer site were younger, had a nodule or a mass, had an unenhanced attenuation of >10 HU, had an SUVmax ratio of >2.5, and had metastasis in other body parts. Analysis found independent associations of age, unenhanced attenuation of >10 HU, SUVmax ratio of >2.5 and the presence of metastasis in other body parts with adrenal metastasis. The combination of the four variables was strongly associated with adrenal metastasis. CONCLUSION: PET/CT was useful in characterising adrenal lesions as benign or malignant and helpful in identifying adrenal metastasis and cancer severity. ADVANCES IN KNOWLEDGE: PET/CT can help in the differential diagnosis between benign and malignant adrenal enlargement.
Authors: Suman Jana; Tong Zhang; David M Milstein; Carmen R Isasi; M Donald Blaufox Journal: Eur J Nucl Med Mol Imaging Date: 2005-09-29 Impact factor: 9.236
Authors: Yon Mi Sung; Kyung Soo Lee; Byung Tae Kim; Joon Young Choi; Myung Jin Chung; Young Mog Shim; Chin A Yi; Tae Sung Kim Journal: Korean J Radiol Date: 2008 Jan-Feb Impact factor: 3.500
Authors: M Trajkovic-Arsic; I Heid; K Steiger; A Gupta; A Fingerle; C Wörner; N Teichmann; S Sengkwawoh-Lueong; P Wenzel; A J Beer; I Esposito; R Braren; J T Siveke Journal: Sci Rep Date: 2017-12-06 Impact factor: 4.379
Authors: Domenico Albano; Francesco Agnello; Federico Midiri; Giusy Pecoraro; Alberto Bruno; Pierpaolo Alongi; Patrizia Toia; Giuseppe Di Buono; Antonino Agrusa; Luca Maria Sconfienza; Salvatore Pardo; Ludovico La Grutta; Massimo Midiri; Massimo Galia Journal: Insights Imaging Date: 2019-01-25