BACKGROUND: Nephrosclerosis/ischemic nephropathy (NS/IN) ranks third among renal diseases requiring dialysis in Japan. Although it is an important renal disease in terms of frequency, its prevalence, new incidence, and risk factors are not fully elucidated. METHODS: We analyzed the prevalence, incidence, concurrent diseases, and risk factors of NS/IN by using data from specific health checkups of Kumamoto citizens between 2008 and 2010. RESULTS: Although the prevalence of NS/IN was 1-2 % in people in their 40s, it increased sharply with age, reaching 17.6 % in people aged 70-74 years. The incidence of new NS/IN was 0.4-0.5 % per year. In multivariate logistic regression analysis, factors such as age, male gender, body mass index (BMI), hyperuricemia, hypertension, and dyslipidemia correlated with NS/IN. When risk factors associated with NS/IN progress were evaluated by multivariate logistic regression analysis, four factors-male gender, hypertension, BMI, and current smoking-significantly correlated. CONCLUSION: The analysis of Kumamoto citizens aged 40-74 years receiving specific health checkups showed that in addition to hypertension and age that were considered important, male gender and obesity are also risk factors for NS/IS independent from hypertension.
BACKGROUND:Nephrosclerosis/ischemic nephropathy (NS/IN) ranks third among renal diseases requiring dialysis in Japan. Although it is an important renal diseasein terms of frequency, its prevalence, new incidence, and risk factors are not fully elucidated. METHODS: We analyzed the prevalence, incidence, concurrent diseases, and risk factors of NS/IN by using data from specific health checkups of Kumamoto citizens between 2008 and 2010. RESULTS: Although the prevalence of NS/IN was 1-2 % inpeoplein their 40s, it increased sharply with age, reaching 17.6 % inpeople aged 70-74 years. The incidence of new NS/IN was 0.4-0.5 % per year. In multivariate logistic regression analysis, factors such as age, male gender, body mass index (BMI), hyperuricemia, hypertension, and dyslipidemia correlated with NS/IN. When risk factors associated with NS/IN progress were evaluated by multivariate logistic regression analysis, four factors-male gender, hypertension, BMI, and current smoking-significantly correlated. CONCLUSION: The analysis of Kumamoto citizens aged 40-74 years receiving specific health checkups showed that in addition to hypertension and age that were considered important, male gender and obesity are also risk factors for NS/IS independent from hypertension.
Authors: K Yamagata; K Ishida; T Sairenchi; H Takahashi; S Ohba; T Shiigai; M Narita; A Koyama Journal: Kidney Int Date: 2006-11-22 Impact factor: 10.612
Authors: Rafael Marín; Manuel Gorostidi; Francisco Fernández-Vega; Rafael Alvarez-Navascués Journal: Kidney Int Suppl Date: 2005-12 Impact factor: 10.545
Authors: Aleksandar Denic; Mariam P Alexander; Vidhu Kaushik; Lilach O Lerman; John C Lieske; Mark D Stegall; Joseph J Larson; Walter K Kremers; Terri J Vrtiska; Harini A Chakkera; Emilio D Poggio; Andrew D Rule Journal: Am J Kidney Dis Date: 2016-02-06 Impact factor: 8.860