| Literature DB >> 23831998 |
Rui Ge1, Yue Zhu, Yao Diao, Lin Tao, Wei Yuan, Xiao-chuan Xiong.
Abstract
Recent studies indicated that epigallocatechin gallate (EGCG) had neuroprotective effects on spinal cord injury (SCI).The current study was performed to determine the anti-edema effect of EGCG after SCI in rats. EGCG (100 mg/kg, i.p.) was administered to rats immediately following SCI. It was found that EGCG (100 mg/kg) could significantly reduce spinal cord water content. In addition, EGCG (100mg/kg) significantly reduced the expression of aquaporin-4(AQP4) and glial fibrillary acidic protein (GFAP) level at 24, 48 and 72h after injury, but it did not have this effect at 12 h after injury. The changes of AQP4 and GFAP protein induced by EGCG (100 mg/kg) treatment were accompanied by a reduction of spinal cord edema. Our results indicated that EGCG (100 mg/kg) could reduce spinal cord edema after SCI, which could be correlated with the down-regulation the expression of AQP4 and GFAP protein level after SCI.Entities:
Keywords: Aquaporin-4; Edema; Epigallocatechin gallate; Glial fibrillary acidic protein; Spinal cord injury
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Year: 2013 PMID： 23831998 DOI： 10.1016/j.brainres.2013.06.009
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252