| Literature DB >> 23831978 |
Aftab A Kandhro1, Abdul Hafeez Laghari, Sarfaraz A Mahesar, Rubina Saleem, Aisha Nelofar, Salman Tariq Khan, S T H Sherazi.
Abstract
A quick and reliable analytical method for the quantitative assessment of cefixime in orally administered pharmaceutical formulations is developed by using diamond cell attenuated total reflectance (ATR) Fourier transform infrared (FT-IR) spectroscopy as an easy procedure for quality control laboratories. The standards for calibration were prepared in aqueous medium ranging from 350 to 6000mg/kg. The calibration model was developed based on partial least square (PLS) using finger print region of FT-IR spectrum in the range from 1485 to 887cm(-1). Excellent coefficient of determination (R(2)) was achieved as high as 0.99976 with root mean square error of 44.8 for calibration. The application of diamond cell (smart accessory) ATR FT-IR proves a reliable determination of cefixime in pharmaceutical formulations to assess the quality of the final product.Entities:
Keywords: Cefixime; Diamond cell-ATR; FT-IR; HPLC; PLS; Quality control
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Year: 2013 PMID： 23831978 DOI： 10.1016/j.saa.2013.06.032
Source DB: PubMed Journal: Spectrochim Acta A Mol Biomol Spectrosc ISSN： 1386-1425 Impact factor: 4.098