OBJECTIVE: Explore whether osteoporosis (OP) in humans influences the morphological status of the articular cartilage and the subchondral bone. Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA). METHODS: Femoral heads after total hip replacement were obtained from patients with OP or hip OA (OP, n = 56; OA, n = 12). Cartilage degeneration was assessed using the Mankin grading system whereas subchondral bone was evaluated using histomorphometry and Micro-computed Tomography (μCT) scanning system. Thickness of the cartilage layers and subchondral cortical bone (SCB) was measured. RESULTS: Samples with higher total Mankin score have significantly reduced cartilage thickness. Mankin score differed between all OP specimens. In OP samples with lower Mankin scores the thickness of SCB shows a trend of an increase caused by increased levels of bone remodeling. In OP samples with higher Mankin scores we observed thinning of SCB. Structural indices of subchondral trabecular bone (STB) were significantly lower in OP than in OA samples. CONCLUSION: Thinning of SCB, found in OP samples with higher Mankin scores could be related with the progression of the cartilage degeneration indicating an early-stage OA. Increased levels of bone remodeling and evidently changed morphology of subchondral bone found in OP samples with lower Mankin score indicated that bony bed level must have a role in the progression of the cartilage degeneration.
OBJECTIVE: Explore whether osteoporosis (OP) in humans influences the morphological status of the articular cartilage and the subchondral bone. Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA). METHODS: Femoral heads after total hip replacement were obtained from patients with OP or hip OA (OP, n = 56; OA, n = 12). Cartilage degeneration was assessed using the Mankin grading system whereas subchondral bone was evaluated using histomorphometry and Micro-computed Tomography (μCT) scanning system. Thickness of the cartilage layers and subchondral cortical bone (SCB) was measured. RESULTS: Samples with higher total Mankin score have significantly reduced cartilage thickness. Mankin score differed between all OP specimens. In OP samples with lower Mankin scores the thickness of SCB shows a trend of an increase caused by increased levels of bone remodeling. In OP samples with higher Mankin scores we observed thinning of SCB. Structural indices of subchondral trabecular bone (STB) were significantly lower in OP than in OA samples. CONCLUSION: Thinning of SCB, found in OP samples with higher Mankin scores could be related with the progression of the cartilage degeneration indicating an early-stage OA. Increased levels of bone remodeling and evidently changed morphology of subchondral bone found in OP samples with lower Mankin score indicated that bony bed level must have a role in the progression of the cartilage degeneration.
Authors: T Jenkins; O L Katsamenis; O G Andriotis; L V Coutts; B Carter; D G Dunlop; R O C Oreffo; C Cooper; N C Harvey; P J Thurner Journal: J Mech Behav Biomed Mater Date: 2017-06-30
Authors: Yan Chen; Yong-Can Huang; Chun Hoi Yan; Kwong Yuen Chiu; Qingjun Wei; Jingmin Zhao; X Edward Guo; Frankie Leung; William W Lu Journal: Bone Res Date: 2017-11-07 Impact factor: 13.567
Authors: Christian Fölsch; Julian Dharma; Carlos Alfonso Fonseca Ulloa; Katrin Susanne Lips; Markus Rickert; Axel Pruss; Alexander Jahnke Journal: Cell Tissue Bank Date: 2020-04-20 Impact factor: 1.522
Authors: Jukka Hirvasniemi; Jérôme Thevenot; Harri T Kokkonen; Mikko A Finnilä; Mikko S Venäläinen; Timo Jämsä; Rami K Korhonen; Juha Töyräs; Simo Saarakkala Journal: Ann Biomed Eng Date: 2015-09-14 Impact factor: 3.934