Literature DB >> 23831412

Exploring the genetic basis of stroke. Spanish stroke genetics consortium.

E Giralt-Steinhauer1, J Jiménez-Conde2, C Soriano Tárraga2, M Mola2, A Rodríguez-Campello2, E Cuadrado-Godia2, A Ois2, I Fernández-Cádenas3, C Carrera3, J Montaner3, R M Díaz Navarro4, C Vives-Bauzá4, J Roquer2.   

Abstract

This article provides an overview of stroke genetics studies ranging from the candidate gene approach to more recent studies by the genome wide association. It highlights the complexity of stroke owing to its different aetiopathogenic mechanisms, the difficulties in studying its genetic component, and the solutions provided to date. The study emphasises the importance of cooperation between the different centres, whether this takes places occasionally or through the creation of lasting consortiums. This strategy is currently essential to the completion of high-quality scientific studies that allow researchers to gain a better knowledge of the genetic component of stroke as it relates to aetiology, treatment, and prevention.
Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Entities:  

Keywords:  Asociación; Association; Consorcio; Consortium; Factores de riesgo genético; Genetic risk factors; Genetics; Genética; Ictus; Predicción; Prediction; Stroke

Mesh:

Year:  2013        PMID: 23831412     DOI: 10.1016/j.nrl.2013.04.005

Source DB:  PubMed          Journal:  Neurologia        ISSN: 0213-4853            Impact factor:   3.109


  3 in total

1.  Association of protein Z and factor VII gene polymorphisms with risk of cerebral hemorrhage: a case-control and a family-based association study in a Chinese Han population.

Authors:  Yi Zeng; Le Zhang; Zhiping Hu; Qidong Yang; Mingming Ma; Baoqiong Liu; Jian Xia; Hongwei Xu; Yunhai Liu; Xiaoping Du
Journal:  J Genet       Date:  2016-06       Impact factor: 1.166

2.  CAMTA1 gene affects the ischemia-reperfusion injury by regulating CCND1.

Authors:  Yang Liu; Guohui Shang; Xuran Zhang; Fuyong Liu; Chi Zhang; Zhihao Li; Jing Jia; Yan Xu; Zhaojing Zhang; Shangdong Yang; Baixue Zhou; Yingying Luan; Yanyang Huang; Yue Peng; Tianyi Han; Ying He; Hong Zheng
Journal:  Front Cell Neurosci       Date:  2022-09-09       Impact factor: 6.147

3.  Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke.

Authors:  Guo-Xiong Deng; Ning Xu; Qi Huang; Jin-Yue Tan; Zhao Zhang; Xian-Feng Li; Jin-Ru Wei
Journal:  Aging (Albany NY)       Date:  2019-09-17       Impact factor: 5.682

  3 in total

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