Literature DB >> 2383122

Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1.

G J Whitman1, D Martel, M Weiss, A Pochanapring, W M See, A Hopeman, A H Harken, I M Dauber.   

Abstract

A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.

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Year:  1990        PMID: 2383122     DOI: 10.1016/0003-4975(90)90758-x

Source DB:  PubMed          Journal:  Ann Thorac Surg        ISSN: 0003-4975            Impact factor:   4.330


  1 in total

1.  Use of epoprostenol to treat severe pulmonary vasoconstriction induced by protamine in cardiac surgery.

Authors:  Zheng Guan; Xin Shen; Yong-Jian Zhang; Xiao-Gang Li; Yan-Feng Gao; Jing Tan; Hui Yuan; Jing-Jie Liu
Journal:  Medicine (Baltimore)       Date:  2018-07       Impact factor: 1.889

  1 in total

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