Literature DB >> 23830937

The p7 protein of hepatitis C virus is degraded via the proteasome-dependent pathway.

Gholamreza Haqshenas1.   

Abstract

The p7 protein of hepatitis C virus (HCV) is a multifunctional, integral membrane protein that plays a critical role in virus life cycle. This study demonstrated that the p7 proteins from different HCV genotypes (GTs) were unstable and degraded via the proteasome-dependent pathway. Mutagenesis analysis of the one and only lysine in JFH1 p7 (K4), the exclusive substrate for ubiquitination, did not stabilize p7 in human hepatoma cells. Collectively, this report demonstrated that p7 is degraded via the proteasome-dependent pathway, and provided evidence suggesting that p7 degradation is an ubiquitin-independent process.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  JFH1; Proteasome; p7

Mesh：

Substances：

Year:  2013        PMID： 23830937     DOI： 10.1016/j.virusres.2013.06.009

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  6 in total

1.  Caspase-Dependent Apoptosis Induction via Viral Protein ORF4 of Porcine Circovirus 2 Binding to Mitochondrial Adenine Nucleotide Translocase 3.

Authors:  Cui Lin; Jinyan Gu; Huijuan Wang; Jianwei Zhou; Jiarong Li; Shengnan Wang; Yulan Jin; Changming Liu; Jue Liu; Hanchun Yang; Ping Jiang; Jiyong Zhou
Journal:  J Virol       Date:  2018-04-27       Impact factor: 5.103

2.  Identification of Putative ORF5 Protein of Porcine Circovirus Type 2 and Functional Analysis of GFP-Fused ORF5 Protein.

Authors:  Qizhuang Lv; Kangkang Guo; Han Xu; Tao Wang; Yanming Zhang
Journal:  PLoS One       Date:  2015-06-02       Impact factor: 3.240

3.  Hepatitis C Virus Nonstructural Protein 5A Inhibits MG132-Induced Apoptosis of Hepatocytes in Line with NF-κB-Nuclear Translocation.

Authors:  Xia Jiang; Tatsuo Kanda; Shuang Wu; Shingo Nakamoto; Masato Nakamura; Reina Sasaki; Yuki Haga; Takaji Wakita; Hiroshi Shirasawa; Osamu Yokosuka
Journal:  PLoS One       Date:  2015-07-02       Impact factor: 3.240

Review 4.  Proteins directly interacting with mammalian 20S proteasomal subunits and ubiquitin-independent proteasomal degradation.

Authors:  Raúl Sánchez-Lanzas; José G Castaño
Journal:  Biomolecules       Date:  2014-12-19

Review 5.  Proteasome- and ethanol-dependent regulation of HCV-infection pathogenesis.

Authors:  Natalia A Osna; Murali Ganesan; Terrence M Donohue
Journal:  Biomolecules       Date:  2014-09-29

6.  Important roles of C-terminal residues in degradation of capsid protein of classical swine fever virus.

Authors:  Yuming Chen; Erpeng Zhu; Shuangqi Fan; Hongxing Ding; Shengming Ma; Mengjiao Zhu; Shaofeng Deng; Jinding Chen; Mingqiu Zhao
Journal:  Virol J       Date:  2019-11-06       Impact factor: 4.099
  6 in total

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