Literature DB >> 23830879

Rho GTPases in neurodegeneration diseases.

Jonathan DeGeer1, Nathalie Lamarche-Vane.   

Abstract

Rho GTPases are molecular switches that modulate multiple intracellular signaling processes by means of various effector proteins. As a result, Rho GTPase activities are tightly spatiotemporally regulated in order to ensure homeostasis within the cell. Though the roles of Rho GTPases during neural development have been well documented, their participation during neurodegeneration has been far less characterized. Herein we discuss our current knowledge of the role and function of Rho GTPases and regulators during neurodegeneration, and highlight their potential as targets for therapeutic intervention in common neurodegenerative disorders.
© 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Nerve injury; Neurite outgrowth; Neurodegeneration; Rho GTPases; RhoGAPs; RhoGEFs

Mesh：

Substances：

Year:  2013        PMID： 23830879     DOI： 10.1016/j.yexcr.2013.06.016

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  21 in total

1.  Creutzfeldt-Jakob Disease Subtype-Specific Regional and Temporal Regulation of ADP Ribosylation Factor-1-Dependent Rho/MLC Pathway at Pre-Clinical Stage.

Authors:  Saima Zafar; Matthias Schmitz; Neelam Younus; Waqas Tahir; Mohsin Shafiq; Franc Llorens; Isidre Ferrer; Olivier Andéoletti; Inga Zerr
Journal:  J Mol Neurosci       Date:  2015-04-21       Impact factor: 3.444

2.  Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promoters.

Authors:  Joanna L MacKay; Sanjay Kumar
Journal:  Integr Biol (Camb)       Date:  2014-09       Impact factor: 2.192

Review 3.  Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research.

Authors:  Ponugoti Vasantha Rao; Padmanabhan P Pattabiraman; Casey Kopczynski
Journal:  Exp Eye Res       Date:  2016-09-01       Impact factor: 3.467

Review 4.  The role of transthyretin in cell biology: impact on human pathophysiology.

Authors:  Joana Magalhães; Márcia Almeida Liz; Jessica Eira
Journal:  Cell Mol Life Sci       Date:  2021-07-23       Impact factor: 9.261

5.  DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.

Authors:  Olivera Story Jovanova; Ivana Nedeljkovic; Derek Spieler; Rosie M Walker; Chunyu Liu; Michelle Luciano; Jan Bressler; Jennifer Brody; Amanda J Drake; Kathryn L Evans; Rahul Gondalia; Sonja Kunze; Brigitte Kuhnel; Jari Lahti; Rozenn N Lemaitre; Riccardo E Marioni; Brenton Swenson; Jayandra Jung Himali; Hongsheng Wu; Yun Li; Allan F McRae; Tom C Russ; James Stewart; Zhiying Wang; Guosheng Zhang; Karl-Heinz Ladwig; Andre G Uitterlinden; Xiuqing Guo; Annette Peters; Katri Räikkönen; John M Starr; Melanie Waldenberger; Naomi R Wray; Eric A Whitsel; Nona Sotoodehnia; Sudha Seshadri; David J Porteous; Joyce van Meurs; Thomas H Mosley; Andrew M McIntosh; Michael M Mendelson; Daniel Levy; Lifang Hou; Johan G Eriksson; Myriam Fornage; Ian J Deary; Andrea Baccarelli; Henning Tiemeier; Najaf Amin
Journal:  JAMA Psychiatry       Date:  2018-09-01       Impact factor: 21.596

6.  Pharmacological Modulators of Small GTPases of Rho Family in Neurodegenerative Diseases.

Authors:  William Guiler; Addison Koehler; Christi Boykin; Qun Lu
Journal:  Front Cell Neurosci       Date:  2021-05-12       Impact factor: 5.505

7.  Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho/ROCK signaling.

Authors:  Frank Roloff; Hannah Scheiblich; Carola Dewitz; Silke Dempewolf; Michael Stern; Gerd Bicker
Journal:  PLoS One       Date:  2015-02-25       Impact factor: 3.240

Review 8.  Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.

Authors:  Yanyang Bai; Xiaoliang Xiang; Chunmei Liang; Lei Shi
Journal:  Biomed Res Int       Date:  2015-03-24       Impact factor: 3.411

9.  Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

Authors:  Laura Civiero; Maria Daniela Cirnaru; Alexandra Beilina; Umberto Rodella; Isabella Russo; Elisa Belluzzi; Evy Lobbestael; Lauran Reyniers; Geshanthi Hondhamuni; Patrick A Lewis; Chris Van den Haute; Veerle Baekelandt; Rina Bandopadhyay; Luigi Bubacco; Giovanni Piccoli; Mark R Cookson; Jean-Marc Taymans; Elisa Greggio
Journal:  J Neurochem       Date:  2015-10-19       Impact factor: 5.372

10.  Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.

Authors:  Jonathan DeGeer; Andrew Kaplan; Pierre Mattar; Morgane Morabito; Ursula Stochaj; Timothy E Kennedy; Anne Debant; Michel Cayouette; Alyson E Fournier; Nathalie Lamarche-Vane
Journal:  J Cell Biol       Date:  2015-08-31       Impact factor: 10.539
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