AIMS: Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults. METHODS: Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of <1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm(2). RESULTS: Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, ASM/weight was found to be independently and negatively associated with serum A-FABP levels. In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO. CONCLUSIONS: The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
AIMS: Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). This study examined the association of SO with serum A-FABP levels in Korean adults. METHODS: Two hundred ninety eight adults aged 20-70 years were examined using dual X-ray absorptiometry and computed tomography and measuring serum A-FABP levels. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (%) of <1 SD below the mean values of young adults in both sexes. Obesity was defined as visceral fat area (VFA) ≥ 100 cm(2). RESULTS: Serum A-FABP levels were higher in groups with SO compared to non-SO groups in both men and women. In the unadjusted model, serum A-FABP levels were positively associated with VFA and negatively associated with ASM/weight. Even after adjusting for possible confounding factors, ASM/weight was found to be independently and negatively associated with serum A-FABP levels. In addition, multiple logistic regression analysis showed that increased serum levels of A-FABP were independently associated with the presence of SO. CONCLUSIONS: The present findings indicate that serum A-FABP levels may be valuable markers of the presence of SO.
Authors: María Esther Rubio-Ruiz; Verónica Guarner-Lans; Israel Pérez-Torres; María Elena Soto Journal: Int J Mol Sci Date: 2019-02-02 Impact factor: 5.923
Authors: Klara Komici; Antonio Dello Iacono; Antonio De Luca; Fabio Perrotta; Leonardo Bencivenga; Giuseppe Rengo; Aldo Rocca; Germano Guerra Journal: Front Endocrinol (Lausanne) Date: 2021-04-15 Impact factor: 5.555
Authors: Tae Nyun Kim; Man Sik Park; You Jeong Kim; Eun Ju Lee; Mi-Kyung Kim; Jung Min Kim; Kyung Soo Ko; Byoung Doo Rhee; Jong Chul Won Journal: PLoS One Date: 2014-06-17 Impact factor: 3.240