OBJECTIVE: To examine the impact of introduction of the mid-trimester scan on pregnancy outcome in cases of open spina bifida in two regions of The Netherlands. METHODS: This was a retrospective cohort study of 190 cases of open spina bifida diagnosed pre- or postnatally, with an estimated date of delivery between 2003 and 2011. RESULTS: With implementation of the mid-trimester scan the percentage of cases of open spina bifida detected before the 24(th) week of pregnancy increased from 43% to 88%. The rise in prenatal detection rate was associated with a significant increase in the number of terminated pregnancies and a decrease in the rate of perinatal loss; the percentage of children born alive did not change significantly. In the subgroup that underwent a scan between 18 and 24 weeks of pregnancy, cranial signs were present in 94.4% of cases. CONCLUSION: Introduction of the mid-trimester scan has led to an increase in early identification of pregnancies complicated by open spina bifida. Pregnancies previously destined to end in perinatal loss are now terminated whilst pregnancies with a relatively good prognosis are frequently continued; the number of children with open spina bifida who are born alive has not changed significantly. Our study confirms that prenatal diagnosis is usually triggered by visualization of a lemon-shaped skull or a banana-shaped cerebellum.
OBJECTIVE: To examine the impact of introduction of the mid-trimester scan on pregnancy outcome in cases of open spina bifida in two regions of The Netherlands. METHODS: This was a retrospective cohort study of 190 cases of open spina bifida diagnosed pre- or postnatally, with an estimated date of delivery between 2003 and 2011. RESULTS: With implementation of the mid-trimester scan the percentage of cases of open spina bifida detected before the 24(th) week of pregnancy increased from 43% to 88%. The rise in prenatal detection rate was associated with a significant increase in the number of terminated pregnancies and a decrease in the rate of perinatal loss; the percentage of children born alive did not change significantly. In the subgroup that underwent a scan between 18 and 24 weeks of pregnancy, cranial signs were present in 94.4% of cases. CONCLUSION: Introduction of the mid-trimester scan has led to an increase in early identification of pregnancies complicated by open spina bifida. Pregnancies previously destined to end in perinatal loss are now terminated whilst pregnancies with a relatively good prognosis are frequently continued; the number of children with open spina bifida who are born alive has not changed significantly. Our study confirms that prenatal diagnosis is usually triggered by visualization of a lemon-shaped skull or a banana-shaped cerebellum.
Authors: Waldo Sepulveda; Amy E Wong; Francisco Sepulveda; Juan L Alcalde; Juan C Devoto; Felipe Otayza Journal: Childs Nerv Syst Date: 2017-06-07 Impact factor: 1.475
Authors: Marian K Bakker; Vijaya Kancherla; Mark A Canfield; Eva Bermejo-Sanchez; Janet D Cragan; Saeed Dastgiri; Hermien E K De Walle; Marcia L Feldkamp; Boris Groisman; Miriam Gatt; Paula Hurtado-Villa; Karin Kallen; Daniella Landau; Nathalie Lelong; Jorge S Lopez Camelo; Laura Martínez; Margery Morgan; Osvaldo M Mutchinick; Wendy N Nembhard; Anna Pierini; Anke Rissmann; Antonin Sipek; Elena Szabova; Giovanna Tagliabue; Wladimir Wertelecki; Ignacio Zarante; Pierpaolo Mastroiacovo Journal: Paediatr Perinat Epidemiol Date: 2019-10-21 Impact factor: 3.980
Authors: Charlotte Rosenkrantz Bodin; Mikkel Mylius Rasmussen; Ann Tabor; Lena Westbom; Eleonor Tiblad; Charlotte Kvist Ekelund; Camilla Bernt Wulff; Ida Vogel; Olav Bjørn Petersen Journal: Biomed Res Int Date: 2018-02-01 Impact factor: 3.411
Authors: Y Kunpalin; J Richter; N Mufti; J Bosteels; S Ourselin; P De Coppi; D Thompson; A L David; J Deprest Journal: BJOG Date: 2021-01 Impact factor: 7.331