Literature DB >> 23828695

Klotho acts as a tumor suppressor in cancers.

Biao Xie1, Jinhui Chen, Bin Liu, Junkun Zhan.   

Abstract

The klotho gene is a classical "aging suppressor" gene. Its roles in the pathology of chronic kidney diseases have been well documented. However, the role of Klotho in tumorigenesis, cancer progression, and prognosis is attracting more and more attention. Recent studies have shown that Klotho participates in the progression of several types of human cancers. Klotho functions as a tumor suppressor by inhibiting insulin/IGF1, p53/p21, and Wnt signaling. Silencing klotho gene expression is mainly mediated through promoter hypermethylation and histone deacetylation in cancer. Klotho has been proposed to take part in cell proliferation, survival, autophagy, and resistance to anti-cancer therapies.

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Year:  2013        PMID： 23828695     DOI： 10.1007/s12253-013-9663-8

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  78 in total

1.  Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung.

Authors:  Jitsuo Usuda; Shuji Ichinose; Taichirou Ishizumi; Keishi Ohtani; Tatsuya Inoue; Hisashi Saji; Masahiro Kakihana; Naohiro Kajiwara; Osamu Uchida; Masaharu Nomura; Hidemitsu Tsutsui; Tatsuo Ohira; Norihiko Ikeda
Journal:  Lung Cancer       Date:  2010-11-13       Impact factor: 5.705

Review 2.  TOR signaling never gets old: aging, longevity and TORC1 activity.

Authors:  Daniel S Evans; Pankaj Kapahi; Wen-Chi Hsueh; Lutz Kockel
Journal:  Ageing Res Rev       Date:  2010-04-10       Impact factor: 10.895

3.  Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells.

Authors:  M Bartucci; C Morelli; L Mauro; S Andò; E Surmacz
Journal:  Cancer Res       Date:  2001-09-15       Impact factor: 12.701

4.  Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes.

Authors:  K Mahadev; X Wu; A Zilbering; L Zhu; J T Lawrence; B J Goldstein
Journal:  J Biol Chem       Date:  2001-10-11       Impact factor: 5.157

5.  Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Authors:  Peggy Kirstetter; Kristina Anderson; Bo T Porse; Sten Eirik W Jacobsen; Claus Nerlov
Journal:  Nat Immunol       Date:  2006-09-03       Impact factor: 25.606

6.  Reactive oxygen species (ROS) in multistage carcinogenesis.

Authors:  Mihalis Panayiotidis
Journal:  Cancer Lett       Date:  2008-03-24       Impact factor: 8.679

7.  "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary.

Authors:  Jacek Zielonka; B Kalyanaraman
Journal:  Free Radic Biol Med       Date:  2008-08-23       Impact factor: 7.376

Review 8.  Klotho gene, phosphocalcic metabolism, and survival in dialysis.

Authors:  Pablo Ureña Torres; Dominique Prié; Laurent Beck; David De Brauwere; Christine Leroy; Gérard Friedlander
Journal:  J Ren Nutr       Date:  2009-01       Impact factor: 3.655

9.  Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549.

Authors:  Bo Chen; Xueli Wang; Weihong Zhao; Jianqing Wu
Journal:  J Exp Clin Cancer Res       Date:  2010-07-19

10.  Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.

Authors:  H Suzuki; M Toyota; H Carraway; H Caraway; E Gabrielson; T Ohmura; T Fujikane; N Nishikawa; Y Sogabe; M Nojima; T Sonoda; M Mori; K Hirata; K Imai; Y Shinomura; S B Baylin; T Tokino
Journal:  Br J Cancer       Date:  2008-02-19       Impact factor: 7.640
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  21 in total

1.  Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells.

Authors:  Sonam Sinha; Samriddhi Shukla; Sajid Khan; Trygve O Tollefsbol; Syed M Meeran
Journal:  Mol Cell Endocrinol       Date:  2015-02-25       Impact factor: 4.102

2.  Klotho suppresses colorectal cancer through modulation of the unfolded protein response.

Authors:  Tammi Arbel Rubinstein; Shiri Shahmoon; Ehud Zigmond; Tal Etan; Keren Merenbakh-Lamin; Metsada Pasmanik-Chor; Gil Har-Zahav; Iris Barshack; Gilad W Vainer; Nir Skalka; Rina Rosin-Arbesfeld; Chen Varol; Tami Rubinek; Ido Wolf
Journal:  Oncogene       Date:  2018-09-19       Impact factor: 9.867

Review 3.  The Emerging Key Role of Klotho in the Hypothalamus-Pituitary-Ovarian Axis.

Authors:  Tingting Xie; Wenting Ye; Jing Liu; Lili Zhou; Yali Song
Journal:  Reprod Sci       Date:  2020-08-11       Impact factor: 3.060

4.  The Involvement of NF-κB/Klotho Signaling in Colorectal Cancer Cell Survival and Invasion.

Authors:  Biao Xie; Shaolin Nie; Gui Hu; Li Xiong; Fan Hu; Mei Li; Tianshu Peng; Jing Nie; Yongheng He
Journal:  Pathol Oncol Res       Date:  2019-01-05       Impact factor: 3.201

5.  Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.

Authors:  Bhoj Raj Adhikari; Osamu Uehara; Hirofumi Matsuoka; Rie Takai; Fumiya Harada; Masafumi Utsunomiya; Takatoshi Chujo; Tetsuro Morikawa; Mamata Shakya; Koki Yoshida; Jun Sato; Toshiya Arakawa; Michiko Nishimura; Hiroki Nagayasu; Itsuo Chiba; Yoshihiro Abiko
Journal:  Med Mol Morphol       Date:  2017-03-16       Impact factor: 2.309

6.  Clinicopathological and Prognostic Significance of Klotho and Estrogen Receptors Expression in Human Hepatocellular Carcinoma.

Authors:  Shu Huang; Wei Wang; Yajun Cheng; Jie Lin; Min Wang
Journal:  Turk J Gastroenterol       Date:  2021-10       Impact factor: 1.852

7.  Inhibition of miR-15b decreases cell migration and metastasis in colorectal cancer.

Authors:  Jian Li; Yuxiang Chen; Xiong Guo; Ling Zhou; Zeming Jia; Yaping Tang; Ling Lin; Weidong Liu; Caiping Ren
Journal:  Tumour Biol       Date:  2016-01-07

Review 8.  Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma.

Authors:  Xiaowei Tang; Yun Wang; Zhining Fan; Guozhong Ji; Min Wang; Jie Lin; Shu Huang; Stephen J Meltzer
Journal:  Lab Invest       Date:  2015-08-03       Impact factor: 5.662

9.  Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity.

Authors:  Riva Shmulevich; Tsipi Ben-Kasus Nissim; Ido Wolf; Keren Merenbakh-Lamin; Daniel Fishman; Israel Sekler; Tami Rubinek
Journal:  Oncogene       Date:  2020-05-12       Impact factor: 9.867

10.  Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma.

Authors:  Margherita Gigante; Giuseppe Lucarelli; Chiara Divella; Giuseppe Stefano Netti; Paola Pontrelli; Cesira Cafiero; Giuseppe Grandaliano; Giuseppe Castellano; Monica Rutigliano; Giovanni Stallone; Carlo Bettocchi; Pasquale Ditonno; Loreto Gesualdo; Michele Battaglia; Elena Ranieri
Journal:  Medicine (Baltimore)       Date:  2015-11       Impact factor: 1.817
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