Literature DB >> 23828523

Cognitive performance of neuromyelitis optica patients: comparison with multiple sclerosis.

Sandra Vanotti1, Evangelina Valeria Cores, Barbara Eizaguirre, Luciana Melamud, Raúl Rey, Andrés Villa.   

Abstract

UNLABELLED: The aim of the present research was to investigate cognitive pattern of patients with neuromyelitis optica (NMO) and to compare it with multiple sclerosis (MS) patients' performance.
METHODS: Fourteen NMO, 14 relapsing remitting multiple sclerosis (RRMS), and 14 healthy control patients participated in the investigation. Neuropsychological functions were evaluated with the Brief Repeatable Neuropsychological Battery for MS; Symbol Digit Modalities Test; Digit Span; and Semantic Fluency.
RESULTS: Fifty-seven percent of NMO patients and 42.85% of the MS ones had abnormal performance in at least two cognitive tests. The NMO Group showed abnormal performance in verbal fluency, verbal and visual memories, with greater attention deficits. NMO patients outperformed healthy control in the paced auditory serial addition test (PASAT). However, no difference was found between NMO and RRMS patients.
CONCLUSIONS: The NMO Group showed more dysfunction in attention and verbal fluencies than in verbal and visual memories. When compared with the MS patients, a similar dysfunction pattern was found. O objetivo da presente pesquisa foi investigar o padrão cognitivo de pacientes com neuromielite óptica (NMO) e compará-lo com o desempenho de pacientes com esclerose múltipla (EM). Métodos: Quatorze pacientes com NMO, 14 com esclerose múltipla recorrente remitente (EMRR) e 14 participantes do Controle saudáveis participaram da presente investigação. As funções neuropsicológicas foram avaliadas com a Bateria Breve de Testes Neuropsicológicos de Rao, Teste Símbolo Digit e a Fluência Semântica. Resultados: Cinquenta e sete por cento dos pacientes com NMO e 42,85% daqueles com EM apresentaram desempenho anormal em pelo menos dois testes cognitivos. O Grupo NMO apresentarou desempenho anormal na fluência verbal e nas memórias visual e verbal, com maiores déficits de atenção. Pacientes com NMO superaram os controles saudáveis em PASAT. No entanto, não foi encontrada diferença entre os pacientes com NMO e aqueles com EMRR. Conclusões: O Grupo NMO mostrou mais disfunção nas fluências de atenção e verbais do que nas memórias verbal e visual. Quando comparados com os pacientes com EM, um padrão de disfunção semelhante foi encontrado.

Entities:  

Mesh:

Year:  2013        PMID: 23828523     DOI: 10.1590/0004-282X20130038

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN: 0004-282X            Impact factor:   1.420


  11 in total

Review 1.  Cognitive dysfunction in adult patients with neuromyelitis optica: a systematic review and meta-analysis.

Authors:  Hao Meng; Jun Xu; Chenling Pan; Jiaxing Cheng; Yue Hu; Yin Hong; Yuehai Shen; Hua Dai
Journal:  J Neurol       Date:  2016-12-01       Impact factor: 4.849

Review 2.  What's new in neuromyelitis optica? A short review for the clinical neurologist.

Authors:  Daniel Whittam; Martin Wilson; Shahd Hamid; Geoff Keir; Maneesh Bhojak; Anu Jacob
Journal:  J Neurol       Date:  2017-03-13       Impact factor: 4.849

3.  Gray Matter Volume Reduction Is Associated with Cognitive Impairment in Neuromyelitis Optica.

Authors:  Q Wang; N Zhang; W Qin; Y Li; Y Fu; T Li; J Shao; L Yang; F-D Shi; C Yu
Journal:  AJNR Am J Neuroradiol       Date:  2015-09-03       Impact factor: 3.825

4.  Treatment of Neuromyelitis Optica Spectrum Disorder: Acute, Preventive, and Symptomatic.

Authors:  Remi A Kessler; Maureen A Mealy; Michael Levy
Journal:  Curr Treat Options Neurol       Date:  2016-01       Impact factor: 3.598

5.  Cognitive functions in Egyptian neuromyelitis optica spectrum disorder.

Authors:  Sara Salama; Hazem Marouf; M Ihab Reda; Amal R Mansour; Osama ELKholy; Michael Levy
Journal:  Clin Neurol Neurosurg       Date:  2019-11-25       Impact factor: 1.876

6.  Multimodal magnetic resonance imaging in relation to cognitive impairment in neuromyelitis optica spectrum disorder.

Authors:  Su-Hyun Kim; Eun Young Park; Boram Park; Jae-Won Hyun; Na Young Park; AeRan Joung; Sang Hyun Lee; Ho Jin Kim
Journal:  Sci Rep       Date:  2017-08-23       Impact factor: 4.379

Review 7.  The Role of Brain-Reactive Autoantibodies in Brain Pathology and Cognitive Impairment.

Authors:  Simone Mader; Lior Brimberg; Betty Diamond
Journal:  Front Immunol       Date:  2017-09-11       Impact factor: 7.561

8.  Cognitive impairment in neuromyelitis optica spectrum disorders: A comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery.

Authors:  Juichi Fujimori; Ichiro Nakashima; Toru Baba; Yuko Meguro; Ryo Ogawa; Kazuo Fujihara
Journal:  eNeurologicalSci       Date:  2017-09-21

9.  Cognitive Impairment in Neuromyelitis Optica.

Authors:  Ahmet Yabalak; Burcu Altunrende; Gülşen Akman Demir
Journal:  Noro Psikiyatr Ars       Date:  2020-04-24       Impact factor: 1.339

Review 10.  Cognitive impairment in NMOSD-More questions than answers.

Authors:  Dominika Czarnecka; Magdalena Oset; Iwona Karlińska; Mariusz Stasiołek
Journal:  Brain Behav       Date:  2020-10-06       Impact factor: 2.708

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