AIM OF THE STUDY: To evaluate a novel esophageal heat transfer device for use in inducing, maintaining, and reversing hypothermia. We hypothesized that this device could successfully induce, maintain (within a 1 °C range of goal temperature), and reverse, mild therapeutic hypothermia in a large animal model over a 30-h treatment protocol. METHODS: Five female Yorkshire swine, weighing a mean of 65 kg (range 61-70) kg each, were anesthetized with inhalational isoflurane via endotracheal intubation and instrumented. The esophageal device was connected to an external chiller and then placed into the esophagus and connected to wall suction. Reduction to goal temperature was achieved by setting the chiller to cooling mode, and a 24h cooling protocol was completed before rewarming and recovering the animals. Histopathologic analysis was scheduled for 3-14 days after protocol completion. RESULTS: Average baseline temperature for the 5 animals was 38.6 °C (range 38.1-39.2 °C). All swine were cooled successfully, with average rate of temperature decrease of 1.3 °C/h (range 1.1-1.9) °C/h. Standard deviation from goal temperature averaged 0.2 °C throughout the steady-state maintenance phase, and no treatment for shivering was necessary during the protocol. Histopathology of esophageal tissue showed no adverse effects from the device. CONCLUSION: A new esophageal heat transfer device successfully and safely induced, maintained, and reversed therapeutic hypothermia in large swine. Goal temperature was maintained within a narrow range, and thermogenic shivering did not occur. These findings suggest a useful new modality to induce therapeutic hypothermia.
AIM OF THE STUDY: To evaluate a novel esophageal heat transfer device for use in inducing, maintaining, and reversing hypothermia. We hypothesized that this device could successfully induce, maintain (within a 1 °C range of goal temperature), and reverse, mild therapeutic hypothermia in a large animal model over a 30-h treatment protocol. METHODS: Five female Yorkshire swine, weighing a mean of 65 kg (range 61-70) kg each, were anesthetized with inhalational isoflurane via endotracheal intubation and instrumented. The esophageal device was connected to an external chiller and then placed into the esophagus and connected to wall suction. Reduction to goal temperature was achieved by setting the chiller to cooling mode, and a 24h cooling protocol was completed before rewarming and recovering the animals. Histopathologic analysis was scheduled for 3-14 days after protocol completion. RESULTS: Average baseline temperature for the 5 animals was 38.6 °C (range 38.1-39.2 °C). All swine were cooled successfully, with average rate of temperature decrease of 1.3 °C/h (range 1.1-1.9) °C/h. Standard deviation from goal temperature averaged 0.2 °C throughout the steady-state maintenance phase, and no treatment for shivering was necessary during the protocol. Histopathology of esophageal tissue showed no adverse effects from the device. CONCLUSION: A new esophageal heat transfer device successfully and safely induced, maintained, and reversed therapeutic hypothermia in large swine. Goal temperature was maintained within a narrow range, and thermogenic shivering did not occur. These findings suggest a useful new modality to induce therapeutic hypothermia.
Authors: Erik B Kulstad; Melissa Naiman; Patrick Shanley; Frank Garrett; Todd Haryu; Donald Waller; Farshid Azarafrooz; Daniel Mark Courtney Journal: BMC Anesthesiol Date: 2015-02-04 Impact factor: 2.217
Authors: Melissa I Naiman; Maria Gray; Joseph Haymore; Ahmed F Hegazy; Andrej Markota; Neeraj Badjatia; Erik B Kulstad Journal: J Vis Exp Date: 2017-11-21 Impact factor: 1.355
Authors: Daniel C Schroeder; Maria Guschlbauer; Alexandra C Maul; Daniel A Cremer; Ingrid Becker; David de la Puente Bethencourt; Peter Paal; Stephan A Padosch; Wolfgang A Wetsch; Thorsten Annecke; Bernd W Böttiger; Anja Sterner-Kock; Holger Herff Journal: PLoS One Date: 2017-03-14 Impact factor: 3.240
Authors: Viktoria Mertin; Patrick Most; Martin Busch; Stefan Trojan; Christian Tapking; Valentin Haug; Ulrich Kneser; Gabriel Hundeshagen Journal: Burns Trauma Date: 2022-09-23