OBJECTIVE: To investigate the feasibility and safety of human bone marrow mesenchymal stem cells (BM-MSCs) transplantation on the improvement of burn wound healing. METHOD: Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs transplantation. RESULTS: We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was found. CONCLUSION: The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future.
OBJECTIVE: To investigate the feasibility and safety of human bone marrow mesenchymal stem cells (BM-MSCs) transplantation on the improvement of burn wound healing. METHOD:Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs transplantation. RESULTS: We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was found. CONCLUSION: The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future.
Authors: E R Chernykh; E Ya Shevela; O Yu Leplina; M A Tikhonova; A A Ostanin; A D Kulagin; N V Pronkina; Zh M Muradov; V V Stupak; V A Kozlov Journal: Bull Exp Biol Med Date: 2006-01 Impact factor: 0.804
Authors: Andrea Gray; Ileana Marrero-Berrios; Mehdi Ghodbane; Timothy Maguire; Jonathan Weinberg; Devasena Manchikalapati; Joseph SchianodiCola; Rene S Schloss; Joel Yarmush Journal: Nano Life Date: 2015-06-01
Authors: Fadi Ghieh; Rosalyn Jurjus; Amir Ibrahim; Alice Gerges Geagea; Hisham Daouk; Bassel El Baba; Sana Chams; Michel Matar; Wadih Zein; Abdo Jurjus Journal: Biomed Res Int Date: 2015-07-07 Impact factor: 3.411
Authors: J J Akershoek; M Vlig; W Talhout; B K H L Boekema; C D Richters; R H J Beelen; K M Brouwer; E Middelkoop; M M W Ulrich Journal: Cell Tissue Res Date: 2015-10-09 Impact factor: 5.249