Literature DB >> 23824986

The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.

Michela Rosini1, Elena Simoni, Manuela Bartolini, Elena Soriano, José Marco-Contelles, Vincenza Andrisano, Barbara Monti, Manfred Windisch, Birgit Hutter-Paier, David W McClymont, Ian R Mellor, Maria Laura Bolognesi.   

Abstract

Entities:  

Keywords:  Alzheimer’s disease; NMDA receptors; acetylcholinesterase; amyloid aggregation; butyrylcholinesterase; dual binding inhibitors

Mesh：

Substances：

Year:  2013        PMID： 23824986     DOI： 10.1002/cmdc.201300263

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


× No keyword cloud information.
  7 in total

Review 1.  Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces.

Authors:  Michela Rosini; Elena Simoni; Anna Minarini; Carlo Melchiorre
Journal:  Neurochem Res       Date:  2014-02-04       Impact factor: 3.996

Review 2.  Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets.

Authors:  Md Sahab Uddin; Abdullah Al Mamun; Md Tanvir Kabir; Ghulam Md Ashraf; May N Bin-Jumah; Mohamed M Abdel-Daim
Journal:  Mol Neurobiol       Date:  2020-09-15       Impact factor: 5.590

Review 3.  Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.

Authors:  Natalia Guzior; Anna Wieckowska; Dawid Panek; Barbara Malawska
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

Review 4.  Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer's Disease Therapy.

Authors:  Agnieszka Zagórska; Anna Jaromin
Journal:  Molecules       Date:  2020-07-23       Impact factor: 4.411

5.  Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile.

Authors:  Galina F Makhaeva; Nadezhda V Kovaleva; Natalia P Boltneva; Elena V Rudakova; Sofya V Lushchekina; Tatiana Yu Astakhova; Igor V Serkov; Alexey N Proshin; Eugene V Radchenko; Vladimir A Palyulin; Jan Korabecny; Ondrej Soukup; Sergey O Bachurin; Rudy J Richardson
Journal:  Molecules       Date:  2022-02-04       Impact factor: 4.411

6.  Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells.

Authors:  Thitima Pewklang; Kantapat Chansaenpak; Rung-Yi Lai; Parinya Noisa; Anyanee Kamkaew
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

7.  New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment.

Authors:  Galina F Makhaeva; Nadezhda V Kovaleva; Natalia P Boltneva; Sofya V Lushchekina; Tatiana Yu Astakhova; Elena V Rudakova; Alexey N Proshin; Igor V Serkov; Eugene V Radchenko; Vladimir A Palyulin; Sergey O Bachurin; Rudy J Richardson
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.