Literature DB >> 23824985

Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism.

Daisuke Ogasawara1, Yukihiro Itoh, Hiroki Tsumoto, Taeko Kakizawa, Koshiki Mino, Kiyoshi Fukuhara, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki.   

Abstract

Keywords:  biological activity; drug delivery; drug design; kinetics; proteins

Mesh：

Substances：

Year:  2013        PMID： 23824985     DOI： 10.1002/anie.201303999

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  17 in total

1.  Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures.

Authors:  Shannon L Nowotarski; Boobalan Pachaiyappan; Steven L Holshouser; Craig J Kutz; Youxuan Li; Yi Huang; Shiv K Sharma; Robert A Casero; Patrick M Woster
Journal:  Bioorg Med Chem       Date:  2015-02-07       Impact factor: 3.641

Review 2.  KDM1 class flavin-dependent protein lysine demethylases.

Authors:  Jonathan M Burg; Jennifer E Link; Brittany S Morgan; Frederick J Heller; Amanda E Hargrove; Dewey G McCafferty
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

Review 3.  Inhibitors of Protein Methyltransferases and Demethylases.

Authors:  H Ümit Kaniskan; Michael L Martini; Jian Jin
Journal:  Chem Rev       Date:  2017-03-24       Impact factor: 60.622

4.  A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers.

Authors:  N Sugino; M Kawahara; G Tatsumi; A Kanai; H Matsui; R Yamamoto; Y Nagai; S Fujii; Y Shimazu; M Hishizawa; T Inaba; A Andoh; T Suzuki; A Takaori-Kondo
Journal:  Leukemia       Date:  2017-02-17       Impact factor: 11.528

5.  Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway.

Authors:  G R Sareddy; S Viswanadhapalli; P Surapaneni; T Suzuki; A Brenner; R K Vadlamudi
Journal:  Oncogene       Date:  2016-11-28       Impact factor: 9.867

6.  Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates.

Authors:  Yosuke Ota; Yukihiro Itoh; Takashi Kurohara; Ritesh Singh; Elghareeb E Elboray; Chenliang Hu; Farzad Zamani; Anirban Mukherjee; Yuri Takada; Yasunobu Yamashita; Mie Morita; Mano Horinaka; Yoshihiro Sowa; Mitsuharu Masuda; Toshiyuki Sakai; Takayoshi Suzuki
Journal:  ACS Med Chem Lett       Date:  2022-09-12       Impact factor: 4.632

7.  KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer.

Authors:  Mei Zhou; Prabhakar Pitta Venkata; Suryavathi Viswanadhapalli; Bridgitte Palacios; Salvador Alejo; Yihong Chen; Yi He; Uday P Pratap; Junhao Liu; Yi Zou; Zhao Lai; Takayoshi Suzuki; Andrew J Brenner; Rajeshwar R Tekmal; Ratna K Vadlamudi; Gangadhara R Sareddy
Journal:  Breast Cancer Res Treat       Date:  2020-10-14       Impact factor: 4.872

8.  Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1.

Authors:  Isuru R Kumarasinghe; Patrick M Woster
Journal:  ACS Med Chem Lett       Date:  2013-11-08       Impact factor: 4.345

9.  Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.

Authors:  Maria E Ourailidou; Alessia Lenoci; Clemens Zwergel; Dante Rotili; Antonello Mai; Frank J Dekker
Journal:  Bioorg Med Chem       Date:  2016-12-01       Impact factor: 3.641

Review 10.  Computer-aided Molecular Design of Compounds Targeting Histone Modifying Enzymes.

Authors:  Federico Andreoli; Alberto Del Rio
Journal:  Comput Struct Biotechnol J       Date:  2015-05-07       Impact factor: 7.271
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