Literature DB >> 23824814

CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice.

Kevin B Walsh1, John Sidney, Megan Welch, Daniel M Fremgen, Alessandro Sette, Michael B A Oldstone.   

Abstract

The paramyxovirus pneumonia virus of mice (PVM) is a rodent model of human respiratory syncytial virus (hRSV) pathogenesis. Here we characterized the PVM-specific CD8(+) T-cell repertoire in susceptible C57BL/6 mice. In total, 15 PVM-specific CD8(+) T-cell epitopes restricted by H-2D(b) and/or H-2K(b) were identified. These data open the door for using widely profiled, genetically manipulated C57BL/6 mice to study the contribution of epitope-specific CD8(+) T cells to PVM pathogenesis.

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Year:  2013        PMID： 23824814      PMCID： PMC3754129          DOI： 10.1128/JVI.00339-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

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8.  Studies on pneumonia virus of mice (PVM) in cell culture. I. Replication in baby hamster kidney cells and properties of the virus.

Authors:  D H Harter; P W Choppin
Journal:  J Exp Med       Date:  1967-08-01       Impact factor: 14.307

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5.  Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.

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