Literature DB >> 23823324

A protein pair with PIPs inside.

Tim P Levine1, Anant K Menon.   

Abstract

Oxysterol binding protein (OSBP) and many of its homologs transfer sterol in vitro, but in vivo, they are not major sterol transporters. In this issue of Structure, Tong and colleagues find that the yeast OSBP homolog, Osh3, binds PI(4)P but not sterol, supporting the view that PI(4)P regulation, not sterol transport, is the key activity for OSBP homologs.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23823324      PMCID： PMC3744641          DOI： 10.1016/j.str.2013.06.010

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  12 in total

1.  The sterol-binding protein Kes1/Osh4p is a regulator of polarized exocytosis.

Authors:  Gabriel Alfaro; Jesper Johansen; Shubha A Dighe; Giselle Duamel; Keith G Kozminski; Christopher T Beh
Journal:  Traffic       Date:  2011-09-12       Impact factor: 6.215

2.  Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites.

Authors:  Christopher J Stefan; Andrew G Manford; Daniel Baird; Jason Yamada-Hanff; Yuxin Mao; Scott D Emr
Journal:  Cell       Date:  2011-02-04       Impact factor: 41.582

3.  Overlapping functions of the yeast oxysterol-binding protein homologues.

Authors:  C T Beh; L Cool; J Phillips; J Rine
Journal:  Genetics       Date:  2001-03       Impact factor: 4.562

4.  Structural mechanism for sterol sensing and transport by OSBP-related proteins.

Authors:  Young Jun Im; Sumana Raychaudhuri; William A Prinz; James H Hurley
Journal:  Nature       Date:  2005-09-01       Impact factor: 49.962

5.  Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM.

Authors:  Alexander G Georgiev; David P Sullivan; Michael C Kersting; Jeremy S Dittman; Christopher T Beh; Anant K Menon
Journal:  Traffic       Date:  2011-07-19       Impact factor: 6.215

6.  Structure of Osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins.

Authors:  Junsen Tong; Huiseon Yang; Hongyuan Yang; Soo Hyun Eom; Young Jun Im
Journal:  Structure       Date:  2013-06-20       Impact factor: 5.006

7.  OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation.

Authors:  Ping-Yuan Wang; Jian Weng; Richard G W Anderson
Journal:  Science       Date:  2005-03-04       Impact factor: 47.728

8.  Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.

Authors:  Maud de Saint-Jean; Vanessa Delfosse; Dominique Douguet; Gaëtan Chicanne; Bernard Payrastre; William Bourguet; Bruno Antonny; Guillaume Drin
Journal:  J Cell Biol       Date:  2011-12-12       Impact factor: 10.539

9.  Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.

Authors:  Timothy A Schulz; Mal-Gi Choi; Sumana Raychaudhuri; Jason A Mears; Rodolfo Ghirlando; Jenny E Hinshaw; William A Prinz
Journal:  J Cell Biol       Date:  2009-12-14       Impact factor: 10.539

10.  Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis.

Authors:  Stuart Forrest; Andrea Chai; Mario Sanhueza; Manuela Marescotti; Katherine Parry; Atanas Georgiev; Virender Sahota; Raquel Mendez-Castro; Giuseppa Pennetta
Journal:  Hum Mol Genet       Date:  2013-03-13       Impact factor: 6.150
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  2 in total

1.  OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells.

Authors:  Guoping Pan; Xiuye Cao; Bo Liu; Chaowen Li; Dan Li; Jie Zheng; Chaofeng Lai; Vesa M Olkkonen; Wenbin Zhong; Daoguang Yan
Journal:  J Biol Chem       Date:  2018-09-20       Impact factor: 5.157

2.  Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.

Authors:  Christopher J Stefan; William S Trimble; Sergio Grinstein; Guillaume Drin; Karin Reinisch; Pietro De Camilli; Sarah Cohen; Alex M Valm; Jennifer Lippincott-Schwartz; Tim P Levine; David B Iaea; Frederick R Maxfield; Clare E Futter; Emily R Eden; Delphine Judith; Alexander R van Vliet; Patrizia Agostinis; Sharon A Tooze; Ayumu Sugiura; Heidi M McBride
Journal:  BMC Biol       Date:  2017-10-31       Impact factor: 7.431
  2 in total

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