Literature DB >> 238233

The binding of tritiated tetrodotoxin to squid giant axons.

S R Levinson, H Meves.   

Abstract

The binding of tetrodotoxin to squid gian axons was determined as a function of toxin concentration, using a tritiated toxin preparation of known radiochemical purity and specific activity. From the amount of saturable binding observed, the number of toxin binding sites thought to be sodium channels was found to be 553 plus or minus 119/mum-2 of axon surface.

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Year:  1975        PMID： 238233     DOI： 10.1098/rstb.1975.0014

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  25 in total

1.  Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation.

Authors:  F Conti; B Hille; B Neumcke; W Nonner; R Stämpfli
Journal:  J Physiol       Date:  1976-11       Impact factor: 5.182

2.  Membrane potential dependent binding of scorpion toxin to action potential Na+ ionophore.

Authors:  W A Catterall; R Ray; C S Morrow
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

3.  The temporal and steady-state relationships between activation of the sodium conductance and movement of the gating particles in the squid giant axon.

Authors:  R D Keynes; E Rojas
Journal:  J Physiol       Date:  1976-02       Impact factor: 5.182

Review 4.  Gating of sodium and potassium channels.

Authors:  F Bezanilla
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

5.  Molecular motion underlying activation and inactivation of sodium channels in squid giant axons.

Authors:  D Landowne
Journal:  J Membr Biol       Date:  1985       Impact factor: 1.843

6.  The conductance and density of sodium channels in the cut-open squid giant axon.

Authors:  J M Bekkers; N G Greeff; R D Keynes
Journal:  J Physiol       Date:  1986-08       Impact factor: 5.182

7.  Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath.

Authors:  J M Ritchie; R B Rogart
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

8.  Ultrastructure of the squid axon membrane as revealed by freeze-fracture electron microscopy.

Authors:  D C Chang; I Tasaki
Journal:  Cell Mol Neurobiol       Date:  1986-03       Impact factor: 5.046

Review 9.  Biochemical investigations of ionic channels in excitable membranes.

Authors:  F Hucho; W Schiebler
Journal:  Mol Cell Biochem       Date:  1977-12-29       Impact factor: 3.396

10.  A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.

Authors:  J M Ritchie; R B Rogart; G R Strichartz
Journal:  J Physiol       Date:  1976-10       Impact factor: 5.182
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