Literature DB >> 238232

The purity of tritiated tetrodotoxin as determined by bioassay.

S R Levinson.   

Abstract

The radioactivity binding of a tritiated tetrodotoxin preparation to an electric organ particulate fraction was compared with the binding of biological activity as determined by biological assay. This comparison shows that the chromatographically homogeneous toxin contained a large proportion of radioactive impurities which bind nonspecifically to the electroplax preparation.

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Year:  1975        PMID： 238232     DOI： 10.1098/rstb.1975.0013

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  13 in total

1.  Proceedings: Binding to nerve and muscle of saxitoxin labelled by a new method of tritium exchange.

Authors:  J M Ritchie; R B Rogart; G Strichartz
Journal:  J Physiol       Date:  1976-06       Impact factor: 5.182

2.  Spontaneous opening at zero membrane potential of sodium channels from eel electroplax reconstituted into lipid vesicles.

Authors:  D S Duch; S R Levinson
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

3.  Neurotoxin-modulated uptake of sodium by highly purified preparations of the electroplax tetrodotoxin-binding glycopeptide reconstituted into lipid vesicles.

Authors:  D S Duch; S R Levinson
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

4.  Immunocytochemical localization of sodium channel distributions in the excitable membranes of Electrophorus electricus.

Authors:  M H Ellisman; S R Levinson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

5.  Electron microscopic visualization of the tetrodotoxin-binding protein from Electrophorus electricus.

Authors:  M H Ellisman; W S Agnew; J A Miller; S R Levinson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

6.  Binding of radioactively labeled saxitoxin to the squid giant axon.

Authors:  G R Strichartz; R B Rogart; J M Ritchie
Journal:  J Membr Biol       Date:  1979-08       Impact factor: 1.843

7.  Saxitoxin binding to sodium channels of rat skeletal muscles.

Authors:  C M Bay; G R Strichartz
Journal:  J Physiol       Date:  1980-03       Impact factor: 5.182

8.  A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves.

Authors:  J M Ritchie; R B Rogart; G R Strichartz
Journal:  J Physiol       Date:  1976-10       Impact factor: 5.182

9.  Binding of scorpion toxin to sodium channels in vitro and its modification by beta-bungarotoxin.

Authors:  H Okamoto
Journal:  J Physiol       Date:  1980-02       Impact factor: 5.182

10.  Purification of the tetrodotoxin-binding component associated with the voltage-sensitive sodium channel from Electrophorus electricus electroplax membranes.

Authors:  W S Agnew; S R Levinson; J S Brabson; M A Raftery
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205
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