Literature DB >> 23822364

8-Channel acquisition system for Time-Correlated Single-Photon Counting.

S Antonioli1, L Miari, A Cuccato, M Crotti, I Rech, M Ghioni.   

Abstract

Nowadays, an increasing number of applications require high-performance analytical instruments capable to detect the temporal trend of weak and fast light signals with picosecond time resolution. The Time-Correlated Single-Photon Counting (TCSPC) technique is currently one of the preferable solutions when such critical optical signals have to be analyzed and it is fully exploited in biomedical and chemical research fields, as well as in security and space applications. Recent progress in the field of single-photon detector arrays is pushing research towards the development of high performance multichannel TCSPC systems, opening the way to modern time-resolved multi-dimensional optical analysis. In this paper we describe a new 8-channel high-performance TCSPC acquisition system, designed to be compact and versatile, to be used in modern TCSPC measurement setups. We designed a novel integrated circuit including a multichannel Time-to-Amplitude Converter with variable full-scale range, a D∕A converter, and a parallel adder stage. The latter is used to adapt each converter output to the input dynamic range of a commercial 8-channel Analog-to-Digital Converter, while the integrated DAC implements the dithering technique with as small as possible area occupation. The use of this monolithic circuit made the design of a scalable system of very small dimensions (95 × 40 mm) and low power consumption (6 W) possible. Data acquired from the TCSPC measurement are digitally processed and stored inside an FPGA (Field-Programmable Gate Array), while a USB transceiver allows real-time transmission of up to eight TCSPC histograms to a remote PC. Eventually, the experimental results demonstrate that the acquisition system performs TCSPC measurements with high conversion rate (up to 5 MHz/channel), extremely low differential nonlinearity (<0.04 peak-to-peak of the time bin width), high time resolution (down to 20 ps Full-Width Half-Maximum), and very low crosstalk between channels.

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Year:  2013        PMID: 23822364     DOI: 10.1063/1.4811377

Source DB:  PubMed          Journal:  Rev Sci Instrum        ISSN: 0034-6748            Impact factor:   1.523


  3 in total

Review 1.  Improving the counting efficiency in time-correlated single photon counting experiments by dead-time optimization.

Authors:  P Peronio; G Acconcia; I Rech; M Ghioni
Journal:  Rev Sci Instrum       Date:  2015-11       Impact factor: 1.523

2.  16-Ch Time-resolved Single-Molecule Spectroscopy Using Line Excitation.

Authors:  Antonino Ingargiola; Pietro Peronio; Eitan Lerner; Angelo Gulinatti; Ivan Rech; Massimo Ghioni; Shimon Weiss; Xavier Michalet
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2017-03-02

3.  A high speed multifocal multiphoton fluorescence lifetime imaging microscope for live-cell FRET imaging.

Authors:  Simon P Poland; Nikola Krstajić; James Monypenny; Simao Coelho; David Tyndall; Richard J Walker; Viviane Devauges; Justin Richardson; Neale Dutton; Paul Barber; David Day-Uei Li; Klaus Suhling; Tony Ng; Robert K Henderson; Simon M Ameer-Beg
Journal:  Biomed Opt Express       Date:  2015-01-06       Impact factor: 3.732

  3 in total

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