Literature DB >> 23821465

Biosynthesis of the natural fluorophore legioliulin from legionella.

Tilman Ahrendt1, Melissa Miltenberger, Ina Haneburger, Ferdinand Kirchner, Max Kronenwerth, Alexander O Brachmann, Hubert Hilbi, Helge B Bode.   

Abstract

Let it shine: The biosynthesis of the UV fluorophore legioliulin (1) from Legionella spp. was elucidated and the phenylalanine ammonium lyase LglD responsible for the formation of the starter unit cinnamic acid was biochemically characterized. Additionally, two novel derivatives differing in the starter unit have been identified by mutasynthesis experiments.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Legionella; biosynthesis; mutagenesis

Mesh：

Substances：

Year:  2013        PMID： 23821465     DOI： 10.1002/cbic.201300373

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  5 in total

1.  Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase.

Authors:  Nicholas J Tobias; Tilman Ahrendt; Ursula Schell; Melissa Miltenberger; Hubert Hilbi; Helge B Bode
Journal:  PeerJ       Date:  2016-11-24       Impact factor: 2.984

2.  Informatic analysis reveals Legionella as a source of novel natural products.

Authors:  Chad W Johnston; Jonathan Plumb; Xiang Li; Sergio Grinstein; Nathan A Magarvey
Journal:  Synth Syst Biotechnol       Date:  2016-02-05

3.  An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor.

Authors:  Rory Little; Felix Trottmann; Miriam Preissler; Christian Hertweck
Journal:  RSC Chem Biol       Date:  2022-07-25

4.  Assembly line termination in cylindrocyclophane biosynthesis: discovery of an editing type II thioesterase domain in a type I polyketide synthase.

Authors:  H Nakamura; J X Wang; E P Balskus
Journal:  Chem Sci       Date:  2015-04-14       Impact factor: 9.825

5.  Genome Mining of Oxidation Modules in trans-Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides.

Authors:  Reiko Ueoka; Roy A Meoded; Alejandro Gran-Scheuch; Agneya Bhushan; Marco W Fraaije; Jörn Piel
Journal:  Angew Chem Int Ed Engl       Date:  2020-03-19       Impact factor: 15.336
  5 in total

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