Literature DB >> 23821351

Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened.

Stefan Peukert1, Feng He, Miao Dai, Rui Zhang, Yingchuan Sun, Karen Miller-Moslin, Michael McEwan, Bharat Lagu, Kate Wang, Naeem Yusuff, Aaron Bourret, Arun Ramamurthy, Wieslawa Maniara, Adam Amaral, Anthony Vattay, Anlai Wang, Ribo Guo, Jing Yuan, John Green, Juliet Williams, Silvia Buonamici, Joseph F Kelleher, Marion Dorsch.   

Abstract

Entities:  

Keywords:  antitumor agents; hedgehog signaling; medicinal chemistry; pyridazines; smoothened inhibitors

Mesh：

Substances：

Year:  2013        PMID： 23821351     DOI： 10.1002/cmdc.201300217

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  21 in total

Review 1.  Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.

Authors:  C A Maschinot; J R Pace; M K Hadden
Journal:  Curr Med Chem       Date:  2015       Impact factor: 4.530

2.  Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.

Authors:  Frederic Bassilana; Adam Carlson; Jennifer A DaSilva; Bianka Grosshans; Solange Vidal; Valerie Beck; Barbara Wilmeringwetter; Luis A Llamas; Todd B Showalter; Pascal Rigollier; Aaron Bourret; Arun Ramamurthy; Xu Wu; Fred Harbinski; Samantha Plonsky; Lac Lee; Heinz Ruffner; Paola Grandi; Markus Schirle; Jeremy Jenkins; Andreas W Sailer; Tewis Bouwmeester; Jeffrey A Porter; Vic Myer; Peter M Finan; John A Tallarico; Joseph F Kelleher; Klaus Seuwen; Rishi K Jain; Sarah J Luchansky
Journal:  Nat Chem Biol       Date:  2014-03-16       Impact factor: 15.040

Review 3.  Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior.

Authors:  Tarapati Rana; Tapan Behl; Aayush Sehgal; Monika Sachdeva; Vineet Mehta; Neelam Sharma; Sukhbir Singh; Simona Bungau
Journal:  Neurochem Res       Date:  2021-03-30       Impact factor: 3.996

4.  CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists.

Authors:  Fang Liu; Wenyan Jiang; Yi Sui; Wei Meng; Linjun Hou; Tiantian Li; Meng Li; Lei Zhang; Jialin Mo; Jiajia Wang; Yang Zhao; Liye Zhang; Jie Ma; Yujie Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-10       Impact factor: 11.205

5.  Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents.

Authors:  Fabrizio Manetti; Barbara Stecca; Roberta Santini; Luisa Maresca; Giuseppe Giannini; Maurizio Taddei; Elena Petricci
Journal:  ACS Med Chem Lett       Date:  2020-03-25       Impact factor: 4.345

Review 6.  Hedgehog Signaling: From Basic Biology to Cancer Therapy.

Authors:  Fujia Wu; Yu Zhang; Bo Sun; Andrew P McMahon; Yu Wang
Journal:  Cell Chem Biol       Date:  2017-03-09       Impact factor: 8.116

7.  RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Authors:  Xuesong Zhao; Tatyana Ponomaryov; Kimberly J Ornell; Pengcheng Zhou; Sukriti K Dabral; Ekaterina Pak; Wei Li; Scott X Atwood; Ramon J Whitson; Anne Lynn S Chang; Jiang Li; Anthony E Oro; Jennifer A Chan; Joseph F Kelleher; Rosalind A Segal
Journal:  Cancer Res       Date:  2015-06-30       Impact factor: 12.701

Review 8.  Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer.

Authors:  Richard L Carpenter; Haimanti Ray
Journal:  Drug Saf       Date:  2019-02       Impact factor: 5.606

9.  The use of hedgehog antagonists in cancer therapy: a comparison of clinical outcomes and gene expression analyses.

Authors:  Burthia E Booker; Adam D Steg; Stefan Kovac; Charles N Landen; Hope M Amm
Journal:  Cancer Biol Ther       Date:  2020-09-11       Impact factor: 4.742

10.  Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Authors:  Chong Wang; Huixian Wu; Tama Evron; Eyal Vardy; Gye Won Han; Xi-Ping Huang; Sandy J Hufeisen; Thomas J Mangano; Dan J Urban; Vsevolod Katritch; Vadim Cherezov; Marc G Caron; Bryan L Roth; Raymond C Stevens
Journal:  Nat Commun       Date:  2014-07-10       Impact factor: 14.919
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