BACKGROUND: Helicobacter pylori is an important causative factor in gastric carcinogenesis. However, its role in extragastric gastrointestinal malignancies, such as colon neoplasia, is controversial. AIM: The aim of this study was to explore the relationship of H. pylori infection with colon neoplasia by meta-analysis of all relevant studies. MATERIALS AND METHODS: Pooled estimates were obtained using fixed or random-effects models as appropriate. Heterogeneity between studies was evaluated using the Cochran Q-test, whereas the likelihood of publication bias was assessed by constructing funnel plots. RESULTS: Among 238 potentially relevant studies, 210 were rejected as unsuitable and 28 studies were finally eligible for meta-analysis, including a total of 33 sets of data (17 on colon cancer and 16 on colon polyps). There was evidence of heterogeneity (I=57.37%); thus, the random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.41 [95% confidence interval 1.24-1.60, P=0.000]. The subgroup meta-analyses showed a significant relationship between H. pylori and colon cancer as well as colon polyps [OR 1.3 (1.07-1.59), P=0.01 and OR 1.5 (1.26-1.79), P=0.000, respectively]. CONCLUSION: The results of this meta-analysis showed a modest statistically significant relationship of H. pylori infection with both colon cancer and polyps.
BACKGROUND:Helicobacter pylori is an important causative factor in gastric carcinogenesis. However, its role in extragastric gastrointestinal malignancies, such as colon neoplasia, is controversial. AIM: The aim of this study was to explore the relationship of H. pyloriinfection with colon neoplasia by meta-analysis of all relevant studies. MATERIALS AND METHODS: Pooled estimates were obtained using fixed or random-effects models as appropriate. Heterogeneity between studies was evaluated using the Cochran Q-test, whereas the likelihood of publication bias was assessed by constructing funnel plots. RESULTS: Among 238 potentially relevant studies, 210 were rejected as unsuitable and 28 studies were finally eligible for meta-analysis, including a total of 33 sets of data (17 on colon cancer and 16 on colon polyps). There was evidence of heterogeneity (I=57.37%); thus, the random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.41 [95% confidence interval 1.24-1.60, P=0.000]. The subgroup meta-analyses showed a significant relationship between H. pylori and colon cancer as well as colon polyps [OR 1.3 (1.07-1.59), P=0.01 and OR 1.5 (1.26-1.79), P=0.000, respectively]. CONCLUSION: The results of this meta-analysis showed a modest statistically significant relationship of H. pyloriinfection with both colon cancer and polyps.
Authors: Nerea Fernández de Larrea-Baz; Angelika Michel; Beatriz Romero; Beatriz Pérez-Gómez; Victor Moreno; Vicente Martín; Trinidad Dierssen-Sotos; José J Jiménez-Moleón; Jesús Castilla; Adonina Tardón; Irune Ruiz; Rosana Peiró; Antonio Tejada; María D Chirlaque; Julia A Butt; Rocío Olmedo-Requena; Inés Gómez-Acebo; Pedro Linares; Elena Boldo; Antoni Castells; Michael Pawlita; Gemma Castaño-Vinyals; Manolis Kogevinas; Silvia de Sanjosé; Marina Pollán; Rosa Del Campo; Tim Waterboer; Nuria Aragonés Journal: Front Microbiol Date: 2017-05-29 Impact factor: 5.640
Authors: Aziza K Mohamed; Nazik M Elhassan; Zahra A Awhag; Fadwa S Ali; Eman T Ali; Najwa A Mhmoud; Emmanuel E Siddig; Rowa Hassan; Eiman S Ahmed; Azam Fattahi; Ayman Ahmed; Mohamed S Muneer; Hussam A Osman; Nouh S Mohamed; Ali M M Edris Journal: BMC Res Notes Date: 2020-07-06
Authors: Hassan Brim; Marwah Zahaf; Adeyinka O Laiyemo; Mehdi Nouraie; Guillermo I Pérez-Pérez; Duane T Smoot; Edward Lee; Hadie Razjouyan; Hassan Ashktorab Journal: BMC Cancer Date: 2014-04-28 Impact factor: 4.430
Authors: Xin-Zu Chen; Ben Schöttker; Felipe Andres Castro; Hongda Chen; Yan Zhang; Bernd Holleczek; Hermann Brenner Journal: Oncotarget Date: 2016-03-29