| Literature DB >> 23819899 |
Jun Li1, Min-Yi Li, Torsten Bruhn, Félix Zongwe Katele, Qiang Xiao, Patchara Pedpradab, Jun Wu, Gerhard Bringmann.
Abstract
Three limonoids named thaixylomolins A-C (1-3), featuring two new motifs, were isolated from the seeds of a Thai mangrove, Xylocarpus moluccensis. The absolute configurations of these limonoids were determined by extensive NMR investigations, single-crystal X-ray diffraction analysis, and circular-dichroism spectroscopy in combination with quantum-chemical calculations. Thaixylomolin B exhibited inhibitory activity against nitric oxide production in lipopolysaccharide and IFN-γ-induced RAW264.7 murine macrophages with an IC50 value of 84.3 μM.Entities:
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Year: 2013 PMID： 23819899 DOI： 10.1021/ol401556m
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005