Literature DB >> 23819792

Mammalian target of rapamycin (mTOR) inhibition does not prevent lung adenocarcinoma-induced malignant pleural effusion.

Maria-Eleni Vazakidou1, Sofia Magkouta1, Charalambos Moschos1, Ioannis Kalomenidis1.   

Abstract

The impact of temsirolimus was investigated in a murine model of malignant pleural effusion (MPE) created with intrapleural injection of Lewis Lung Cancer (LLC) cells. Temsirolimus (1 or 20 mg/kg) did not affect the pleural fluid volume or the number of pleural tumour foci. In addition, temsirolimus did not affect vascular endothelial growth factor expression by LLC cells in vitro. In conclusion, temsirolimus did not curtail experimental lung-adenocarcinoma-induced MPE.
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.

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Keywords:  animal model; lung cancer; molecular biology; pleural disease

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Year:  2013        PMID： 23819792     DOI： 10.1111/resp.12151

Source DB:  PubMed          Journal:  Respirology        ISSN： 1323-7799            Impact factor:   6.424


  2 in total

Review 1.  Switching off malignant pleural effusion formation-fantasy or future?

Authors:  Magda Spella; Anastasios D Giannou; Georgios T Stathopoulos
Journal:  J Thorac Dis       Date:  2015-06       Impact factor: 2.895

2.  Intrapleural targeted therapies (anti-VEGF and anti-EGFR) in the model of malignant pleural effusion.

Authors:  Milena Marques Pagliarelli Acencio; Juliana Puka; Vanessa Adélia Alvarenga; Vanessa Martins; Mariana Lombardi Peres de Carvalho; Evaldo Marchi; Vera Luiza Capelozzi; Lisete Ribeiro Teixeira
Journal:  Oncotarget       Date:  2017-09-28
  2 in total

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