Literature DB >> 23817501

Erectile function and late-onset hypogonadism symptoms related to lower urinary tract symptom severity in elderly men.

Ozan Bozkurt1, Deniz Bolat, Omer Demir, Oktay Ucer, Ali Sahin, Burak Ozcift, Abdulkadir Pektaş, Tahir Turan, Bilal H Gümüş, Ertan Can, Ahmet Bolukbasi, Haluk Erol, Adil Esen.   

Abstract

The aim of this study was to evaluate the relationship between lower urinary tract symptoms (LUTSs), erectile dysfunction (ED) and symptomatic late-onset hypogonadism (SLOH) in ageing men in the Aegean region of Turkey. Five hundred consecutive patients >40 years old who had been in a steady sexual relationship for the past 6 months and were admitted to one of six urology clinics were included in the study. Serum prostate-specific antigen and testosterone levels and urinary flow rates were measured. All patients filled out the International Prostate Symptom Score and Quality of Life (IPSS-QoL), International Index of Erectile Function (IIEF) and Aging Males' Symptoms (AMS) scale forms. Of the patients, 23.9% had mild LUTSs, 53.3% had moderate LUTSs and 22.8% had severe LUTSs. The total testosterone level did not differ between groups. Additionally, 69.6% had ED. The presence of impotence increased with increasing LUTS severity. Symptomatic late-onset hypogonadism (AMS >27) was observed in 71.2% of the patients. The prevalence of severe hypogonadism symptoms increased with the IPSS scores. A correlation analysis revealed that all three questionnaire scores were significantly correlated. In conclusion, LUTS severity is an age-independent risk factor for ED and SLOH. LUTS severity and SLOH symptoms appear to have a strong link that requires etiological and biological clarification in future studies.

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Year:  2013        PMID: 23817501      PMCID: PMC3854042          DOI: 10.1038/aja.2013.44

Source DB:  PubMed          Journal:  Asian J Androl        ISSN: 1008-682X            Impact factor:   3.285


  34 in total

1.  Investigation, treatment and monitoring of late-onset hypogonadism in males. Official recommendations of ISSAM. International Society for the Study of the Aging Male.

Authors:  A Morales; B Lunenfeld
Journal:  Aging Male       Date:  2002-06       Impact factor: 5.892

2.  Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations.

Authors:  E Nieschlag; R Swerdloff; H M Behre; L J Gooren; J M Kaufman; J-J Legros; B Lunenfeld; J E Morley; C Schulman; C Wang; W Weidner; F C W Wu
Journal:  Eur Urol       Date:  2005-07       Impact factor: 20.096

3.  The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association.

Authors:  M J Barry; F J Fowler; M P O'Leary; R C Bruskewitz; H L Holtgrewe; W K Mebust; A T Cockett
Journal:  J Urol       Date:  1992-11       Impact factor: 7.450

4.  The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction.

Authors:  R C Rosen; A Riley; G Wagner; I H Osterloh; J Kirkpatrick; A Mishra
Journal:  Urology       Date:  1997-06       Impact factor: 2.649

5.  Co-localization of androgen receptor with estrogen receptor beta in the lower urinary tract of the male rat.

Authors:  S Salmi; R Santti; J A Gustafsson; S Mäkelä
Journal:  J Urol       Date:  2001-08       Impact factor: 7.450

6.  Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study.

Authors:  Andre B Araujo; Amy B O'Donnell; Donald J Brambilla; William B Simpson; Christopher Longcope; Alvin M Matsumoto; John B McKinlay
Journal:  J Clin Endocrinol Metab       Date:  2004-12       Impact factor: 5.958

7.  Some pre- and postjunctional effects of castration in rabbit isolated corpus cavernosum and urethra.

Authors:  F Holmquist; K Persson; A Bødker; K E Anderson
Journal:  J Urol       Date:  1994-09       Impact factor: 7.450

8.  Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study.

Authors:  H A Feldman; I Goldstein; D G Hatzichristou; R J Krane; J B McKinlay
Journal:  J Urol       Date:  1994-01       Impact factor: 7.450

9.  Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7).

Authors:  Raymond Rosen; Jens Altwein; Peter Boyle; Roger S Kirby; B Lukacs; Eric Meuleman; Michael P O'Leary; Paolo Puppo; Chris Robertson; Francois Giuliano
Journal:  Eur Urol       Date:  2003-12       Impact factor: 20.096

10.  Location and concentration of estrogen, progesterone, and androgen receptors in the bladder and urethra of the rabbit.

Authors:  B A Rosenzweig; P S Bolina; L Birch; C Moran; I Marcovici; G S Prins
Journal:  Neurourol Urodyn       Date:  1995       Impact factor: 2.696

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  1 in total

Review 1.  Testosterone Replacement Therapy on the Natural History of Prostate Disease.

Authors:  Aaron Moore; Michael J Butcher; Tobias S Köhler
Journal:  Curr Urol Rep       Date:  2015-08       Impact factor: 3.092

  1 in total

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