[The combined action of glucocorticoid hormones and interleukin-1 on the development of an immune response].

The effect of interleukin-I (IL-I) on glucocorticoid-induced inhibition of the immune response and reactions of cyclic nucleotides to antigen was studied on a model with the use of purified IL-I preparation. Hydrocortisone (HC) in the applied dose caused suppression of the immune response and sharp inhibition of antigen-induced reactions--cAMP in 10 minutes and cGMP on the 6th day after immunization. IL-I administered 10 minutes prior to HC and before immunization prevented the immunosuppressive effect of HC completely. Control administration of heated IL-I and in inactive fraction of the preparation failed to produce a similar effect. IL-I injected 10 minutes after HC also inhibited immunosuppression.