Literature DB >> 23817237

ULK1 targets Beclin-1 in autophagy.

Volodymyr Y Nazarko, Qing Zhong.   

Abstract

The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.

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Year:  2013        PMID： 23817237      PMCID： PMC4442023          DOI： 10.1038/ncb2797

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Rubicon controls endosome maturation as a Rab7 effector.

Authors:  Qiming Sun; Wiebke Westphal; Kwun Ngok Wong; Irena Tan; Qing Zhong
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

2.  Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.

Authors:  Chengyu Liang; Pinghui Feng; Bonsu Ku; Iris Dotan; Dan Canaani; Byung-Ha Oh; Jae U Jung
Journal:  Nat Cell Biol       Date:  2006-06-25       Impact factor: 28.824

3.  Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

Authors:  Kohichi Matsunaga; Tatsuya Saitoh; Keisuke Tabata; Hiroko Omori; Takashi Satoh; Naoki Kurotori; Ikuko Maejima; Kanae Shirahama-Noda; Tohru Ichimura; Toshiaki Isobe; Shizuo Akira; Takeshi Noda; Tamotsu Yoshimori
Journal:  Nat Cell Biol       Date:  2009-03-08       Impact factor: 28.824

Review 4.  The role of the Atg1/ULK1 complex in autophagy regulation.

Authors:  Noboru Mizushima
Journal:  Curr Opin Cell Biol       Date:  2010-01-06       Impact factor: 8.382

5.  DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

Authors:  Einat Zalckvar; Hanna Berissi; Liat Mizrachy; Yulia Idelchuk; Itay Koren; Miriam Eisenstein; Helena Sabanay; Ronit Pinkas-Kramarski; Adi Kimchi
Journal:  EMBO Rep       Date:  2009-01-30       Impact factor: 8.807

6.  Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

Authors:  Qiming Sun; Weiliang Fan; Keling Chen; Xiaojun Ding; She Chen; Qing Zhong
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-02       Impact factor: 11.205

7.  The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.

Authors:  Sabrina Di Bartolomeo; Marco Corazzari; Francesca Nazio; Serafina Oliverio; Gaia Lisi; Manuela Antonioli; Vittoria Pagliarini; Silvia Matteoni; Claudia Fuoco; Luigi Giunta; Marcello D'Amelio; Roberta Nardacci; Alessandra Romagnoli; Mauro Piacentini; Francesco Cecconi; Gian Maria Fimia
Journal:  J Cell Biol       Date:  2010-10-04       Impact factor: 10.539

8.  Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.

Authors:  Yun Zhong; Qing Jun Wang; Xianting Li; Ying Yan; Jonathan M Backer; Brian T Chait; Nathaniel Heintz; Zhenyu Yue
Journal:  Nat Cell Biol       Date:  2009-03-08       Impact factor: 28.824

9.  Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

Authors:  Eisuke Itakura; Chieko Kishi; Kinji Inoue; Noboru Mizushima
Journal:  Mol Biol Cell       Date:  2008-10-08       Impact factor: 4.138

10.  SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.

Authors:  Yuxia Zhang; Libo Yan; Zhi Zhou; Peiguo Yang; E Tian; Kai Zhang; Yu Zhao; Zhipeng Li; Bing Song; Jinghua Han; Long Miao; Hong Zhang
Journal:  Cell       Date:  2009-01-23       Impact factor: 41.582
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  39 in total

1.  [Expression rhythm of autophagic gene in neurons of neonatal rats with hypoxia/ischemia and its regulatory mechanism].

Authors:  Shi-Ping Li; Jiang-Hu Zhu; Feng-Yan Zhao; Zhen Zheng; De-Zhi Mu; Yi Qu
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2017-08

2.  HIV-1 Antisense Protein of Different Clades Induces Autophagy and Associates with the Autophagy Factor p62.

Authors:  Zhenlong Liu; Cynthia Torresilla; Yong Xiao; Phuong Trang Nguyen; Clément Caté; Karina Barbosa; Éric Rassart; Shan Cen; Steve Bourgault; Benoit Barbeau
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

Review 3.  Oxidative stress, autophagy and airway ion transport.

Authors:  Scott M O'Grady
Journal:  Am J Physiol Cell Physiol       Date:  2018-10-10       Impact factor: 4.249

4.  Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.

Authors:  Cun-Jin Su; Yu Feng; Teng-Teng Liu; Xu Liu; Jun-Jie Bao; Ai-Ming Shi; Duan-Min Hu; Tong Liu; Yun-Li Yu
Journal:  CNS Neurosci Ther       Date:  2017-07-29       Impact factor: 5.243

5.  A role for autophagy in long-term spatial memory formation in male rodents.

Authors:  Michael J Hylin; Jing Zhao; Karthikeyan Tangavelou; Natalia S Rozas; Kimberly N Hood; Jacalyn S MacGowan; Anthony N Moore; Pramod K Dash
Journal:  J Neurosci Res       Date:  2017-12-12       Impact factor: 4.164

Review 6.  Key roles of autophagy in regulating T-cell function.

Authors:  Yair Botbol; Ignacio Guerrero-Ros; Fernando Macian
Journal:  Eur J Immunol       Date:  2016-06       Impact factor: 5.532

7.  Autophagy Promotes Replication of Influenza A Virus In Vitro.

Authors:  Ruifang Wang; Yinxing Zhu; Jiachang Zhao; Chenwei Ren; Peng Li; Huanchun Chen; Meilin Jin; Hongbo Zhou
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

Review 8.  AMPK: a key regulator of energy stress and calcium-induced autophagy.

Authors:  Rimpi Saikia; Jomon Joseph
Journal:  J Mol Med (Berl)       Date:  2021-08-16       Impact factor: 4.599

9.  Association of the expression of unc-51-Like kinase 1 with lymph node metastasis and survival in patients with esophageal squamous cell carcinoma.

Authors:  Lin Jiang; Ben-Song Duan; Jun-Xing Huang; Xia Jiao; Xiao-Wei Zhu; Hai-Hui Sheng; Heng-Jun Gao; Hong Yu
Journal:  Int J Clin Exp Med       Date:  2014-05-15

Review 10.  MicroRNA regulation of autophagy in cardiovascular disease.

Authors:  Matthew A Sermersheim; Ki Ho Park; Kristyn Gumpper; T M Ayodele Adesanya; Kuncheng Song; Tao Tan; Xingcong Ren; Jin-Ming Yang; Hua Zhu
Journal:  Front Biosci (Landmark Ed)       Date:  2017-01-01
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