| Literature DB >> 23817101 |
Yun-Jeong Son1, In-Soo Yoon, Jong-Hyuk Sung, Hyun-Jong Cho, Suk-Jae Chung, Chang-Koo Shim, Dae-Duk Kim.
Abstract
The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.Entities:
Keywords: Chondrogenic differentiation; Human adipose-derived stem cells; Hyaluronic acid; Interpenetrating polymeric network; Sodium alginate
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Year: 2013 PMID： 23817101 DOI： 10.1016/j.ijbiomac.2013.06.023
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953