Evaluation of in vivo anti-inflammatory and analgesic activities of novel derivatives of Ugi-4CR.

In the present research, anti-inflammatory and analgesic activities of the synthesized agents derived from Ugi four-component reaction (Ugi-4CR) have been described. The synthesis was initiated by the imine formation under microwave irradiation. Ugi-4CR adducts has been achieved by the condensation of imine with aromatic aldehyde, 4- aminoantipyrine and ethylisocyanoacetate. The reaction was carried out at room temperature in presence of Fluorite as a catalyst. The novel Ugi derivatives were characterized on the basis of IR, 1H NMR, 13C NMR, Mass and Elemental analysis. All the synthesized agents were screened for their potential anti-inflammatory and analgesic activities using healthy wistar albino rats. Anti-inflammatory and analgesic activities were evaluated by Mercury displacement and Hot plate method using Diclofenac and Morphine Sulfate as standard reference drugs respectively. The screening data shows that synthesized compounds are potent agents to act as analgesic and anti-inflammatory drugs.