| Literature DB >> 2381502 |
E Nilsson1, I Alafuzoff, K Blennow, K Blomgren, C M Hall, I Janson, I Karlsson, A Wallin, C G Gottfries, J O Karlsson.
Abstract
The Ca2(+)-dependent neutral proteases calpain I and II as well as their specific inhibitor, calpastatin, were isolated from normal and Alzheimer-degenerated frozen human brain tissue. In the Alzheimer group calpain I activity was higher in cortex than in mesencephalon. The calpastatin activity was lower in cortex in both groups. This may implicate a higher Ca2(+)-dependent proteolysis in cortex compared to mesencephalon. In the Alzheimer group the cortical calpain II level decreased with an increasing degree of neuropathological changes. In the control group, the level of calpastatin decreased as the number of plaques and tangles increased. Evidence was obtained for a correlation of net calpain activity and the extent of neuropathological changes in cortex.Entities:
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Year: 1990 PMID： 2381502 DOI： 10.1016/0197-4580(90)90009-o
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673