Eosinophilic small bowel enteritis in response to folinic acid, fluorouracil, and oxaliplatin chemotherapy.

A 70-year-old woman being treated with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) therapy for relapsed colon cancer metastatic to the lung presented to the hospital with a 1-week history of abdominal pain, anorexia, a 1-day history of diarrhea, and a fever of 101°F. Neutropenia and a peripheral eosinophilia were present, and computed tomogram of the abdomen showed thickening of the wall of a segment of small bowel with luminal stenosis. Colonoscopy and double-balloon small bowel enteroscopy found a stenosis in the ileum that upon biopsy revealed small bowel eosinophilic enteritis. She improved rapidly with the administration of dexamethasone. A Medline search for reports of small bowel eosinophilic enteritis in response to any of the components of FOLFOX was unrevealing.