Effectiveness and safety of Gamma Knife radiosurgery for glossopharyngeal neuralgia.

Glossopharyngeal neuralgia (GPN) is a rare disorder of the ninth cranial nerve characterized by severe paroxysmal pain affecting the ear, tongue, and throat. GPN can be associated with life-threatening issues such as cardiac arrhythmias, syncope, or malnutrition and weight loss from odynophagia. Though traditional treatment for GPN involves medical management at first and surgery for refractory cases, these therapies are often poorly tolerated in the elderly population. We describe the case of a 99-year-old woman, the oldest reported patient with GPN treated successfully with Gamma Knife radiosurgery. We conclude that Gamma Knife radiosurgery for GPN can be both effective and very well tolerated in the elderly and deserves further study and careful consideration as a treatment option in this population.