Literature DB >> 23813808

Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.

Yunlong Zhang1, Jeisa M Pelet, Daniel A Heller, Yizhou Dong, Delai Chen, Zhen Gu, Brian J Joseph, Jasmine Wallas, Daniel G Anderson.   

Abstract

Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  aminoglycoside; drug delivery; gene knockdown; nanoparticle; siRNA

Mesh：

Substances：

Year:  2013        PMID： 23813808      PMCID： PMC3898629          DOI： 10.1002/adma.201301917

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  41 in total

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Authors: 
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  13 in total

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4.  Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles.

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