Literature DB >> 23813499

Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides.

Helene Bach1, Yung-Yu Huang, Mark D Underwood, Andrew J Dwork, J John Mann, Victoria Arango.   

Abstract

Using high pressure liquid chromatography, we find more brainstem 5-HT and 5-HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5-HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.
Copyright © 2013 Wiley Periodicals, Inc.

Entities:  

Keywords:  5-HIAA; brainstem; prefrontal cortex; raphe; serotonin; suicide

Mesh：

Substances：

Year:  2013        PMID： 23813499      PMCID： PMC3872491          DOI： 10.1002/syn.21695

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  33 in total

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Authors:  J John Mann
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Authors:  K G Lloyd; I J Farley; J H Deck; O Hornykiewicz
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