PURPOSE: During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology. METHODS: The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (n = 5) and phenylephrine (n = 7) infusion. RESULTS: Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm, P = 0.025; 95.7 vs. 215.5 mm/s, P = 0.0074; 35.3 vs. 83.6 m/s(2), P = 0.0096 and -35.6 vs. -83.6 m/s(2), P = 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm, P = 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly. CONCLUSIONS: The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline.
PURPOSE: During off-pump coronary artery bypass (OPCAB), surgeons are required to perform a precise anastomosis on the beating heart. The hypotension caused by vertical displacement of the heart during OPCAB is usually treated with vasopressors, such as noradrenaline and phenylephrine. However, the effects of these agents on coronary artery motion are unknown. The present study analyzed the motion of the target coronary arteries during noradrenaline or phenylephrine infusion using three-dimensional motion capture and reconstruction technology. METHODS: The left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) of 12 female landrace pigs (weight 50 ± 1 kg) were stabilized using a tissue stabilizer. The motions in the regions were captured before and during noradrenaline (n = 5) and phenylephrine (n = 7) infusion. RESULTS:Noradrenaline (0.15 μg/kg/min) and phenylephrine (1.1 μg/kg/min) significantly increased the blood pressure. Noradrenaline significantly increased the motion parameters, such as the distance moved, maximum velocity, acceleration and deceleration at the LAD (4.2 vs. 7.9 mm, P = 0.025; 95.7 vs. 215.5 mm/s, P = 0.0074; 35.3 vs. 83.6 m/s(2), P = 0.0096 and -35.6 vs. -83.6 m/s(2), P = 0.005, respectively). The values during phenylephrine infusion did not change except for the distance moved at the LAD (3.8 vs. 7.7 mm, P = 0.042). The motion parameters at the LCX and RCA during noradrenaline and phenylephrine infusion did not change significantly. CONCLUSIONS: The effect of phenylephrine on the coronary artery motion was less dramatic than that of noradrenaline.
Authors: Brack Hattler; John C Messenger; A Laurie Shroyer; Joseph F Collins; Scott J Haugen; Joel A Garcia; Janet H Baltz; Joseph C Cleveland; Dimitri Novitzky; Frederick L Grover Journal: Circulation Date: 2012-05-16 Impact factor: 29.690
Authors: A Laurie Shroyer; Frederick L Grover; Brack Hattler; Joseph F Collins; Gerald O McDonald; Elizabeth Kozora; John C Lucke; Janet H Baltz; Dimitri Novitzky Journal: N Engl J Med Date: 2009-11-05 Impact factor: 91.245
Authors: Dan Chalothorn; Dan F McCune; Stephanie E Edelmann; Kimimasa Tobita; Bradley B Keller; Robert D Lasley; Dianne M Perez; Akito Tanoue; Gozoh Tsujimoto; Ginell R Post; Michael T Piascik Journal: J Pharmacol Exp Ther Date: 2003-03-20 Impact factor: 4.030
Authors: Edward L Hannan; Chuntao Wu; Craig R Smith; Robert S D Higgins; Russell E Carlson; Alfred T Culliford; Jeffrey P Gold; Robert H Jones Journal: Circulation Date: 2007-08-20 Impact factor: 29.690
Authors: Dominik P Guensch; Kady Fischer; Christof Jung; Samuel Hurni; Bernhard M Winkler; Bernd Jung; Andreas P Vogt; Balthasar Eberle Journal: PLoS One Date: 2019-01-16 Impact factor: 3.240